用WT小鼠肝总裂解液免疫沉淀Nrf2,然后检测蛋白间结合。数据表明,在WT肝脏中,Nrf2可以结合HNF4α和cMyc。此外,Nrf2 ChIP分析结果显示HFN4α-KO小鼠中Nrf2 DNA结合减少,与WT和HNF4α-KO小鼠相比,DKO小鼠中Nrf2 DNA结合明显增加(图7F)...
另外,紫檀芪(20μmol/L)显著上调氧化应激MC3T3-E1中c-myc和Nrf2的蛋白表达量(**P<0.01).干扰c-myc表达可有效抑制紫檀芪对氧化应激MC3T3-E1的Nrf2蛋白表达量(**P<0.01),细胞活力(**P<0.01),LDH漏出量(**P<0.01),caspase-3活性(**P<0.01)和ROS水平(**P<0.01)的作用.结论 紫檀芪可通过c-myc调控Nrf2表达...
Nrf2c-myc癌基因Western-Blot检测法目的:探讨小细胞肺癌c-myc癌基因的表达对Nrf2表达的影响,分析c-myc与 Nrf2表达的相关性.方法:选用两株耐药性不同的肺小细胞癌肿瘤细胞株,小细胞肺癌药物敏感株H69及耐药株H69AR,Westem-B10t方法比 较Nrf2,c-myc在两株细胞间的表达差异;H69细胞通过Lipofectamine2000脂质体转染...
目的观察前列腺癌组织中Nrf2,c-Myc蛋白的表达变化,并探讨其临床意义.方法采用免疫组化SP法检测42例份前列腺癌组织,50例份前列腺正常组织中Nrf2,c-Myc蛋白表达,分析Nrf2及c-Myc蛋白阳性表达与列腺癌患者临床病理特征的关系,用Spearman相关分析Nrf2与c-Myc蛋白阳性表达的相关性.结果前列腺癌组织中Nrf2,c-Myc蛋白阳性表...
MYC is involved in the regulation of NRF2 activity by salicylate. First, we analyzed 13 public Gene Expression Omnibus (GEO) datasets for the effects of ectopic expression or knockdown/knockout ofc-MYCin cell lines or mice onNQO1expression. Notably, the NRF2 target geneNQO1was repressed after ...
cells Article NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion Peter Sang Uk Park 1 , Se Hwan Mun 1, Steven L. Zeng 1, Haemin Kim 1,2, Seyeon Bae 1,2,* and Kyung-Hyun Park-Min 1,2,3,* 1 Arthritis and Tissue Degeneration Program, David ...
人物简介: 一、李源担任职务:李源目前担任连山壮族瑶族自治县山城市场19-20号档法定代表人;二、李源投资情况:目前李源投资连山壮族瑶族自治县山城市场19-20号档最终收益股份为0%;老板履历 图文概览商业履历 任职全景图 投资、任职的关联公司 商业关系图 一图看清商业版图 ...
Activation of cnc/Nrf2 is required for Myc-induced overgrowth.Peter NagyÁgnes VargaKarolina PircsKrisztina HegedusGabor Juhasz
Kelvin J.A. Davies a bHenry Jay Forman aFree Radical Biology and Medicine
Treatments for 24 h showed a dose-dependent reduction in BCL2/BAX, c-MYC/BAX and HO-1/BAX ratios. The exception was the NRF2/BAX ratio, showing a dose-dependent reduction at low doses, but a marked increase at the highest dose. The hTERT/BAX ratio was maintained at approximately a ...