and subsequent c-Maf degradation.Mebendazole inhibited c-Maf transcriptional activity,as confirmed by both luciferase assays and expression measurements of c-Maf downstream genes.In summary,this study identified mebendazole as a USP5/c-Maf inhibitor that could be developed as a novel antimyeloma agent...
Notably, suppression of USP5 by its inhibitor WP1130 leads to MM cell apoptosis in association with increased c-Maf ubiquitination and degradation. Although WP1130 probably inhibits several deubiquitinases including USP5, USP9X, and others,14 when USP5 was knocked down, the effects of WP1130 ...
Inhibition of MAPK/ERK1/2 activity by MEK1/2 inhibitor AZD6244 (ARRY-142886) induces human multiple myeloma (MM) cell apoptosis and blocks MM interactions within the bone marrow microenvironment: a new therapeutic strategy for MM (STAT3, Bcl-2, cyclin E1, CDK1, -3, -7, p21/Cdc42/Rac1...
with OTUB1 and c-Maf plasmids for 24 hrs, followed by WB and it showed that OTUB1 upregulated c-Maf protein. Moreover, when MM cell line RPMI-8226 was infected with lentiviral OTUB1, c-Maf in RPMI-8226 cells were also increased. When cells were treated with CHX, an inhibitor of ...
at least in mice. Prox1-deficient mice do not express γB or γD crystallins and fail to increase the levels of the cyclin-dependent kinase inhibitor, p57Kip2, which likely explains the failure of lens cells from this mutant to withdraw from the cell cycle. Another transcription factor, Pi...
。在一些方面,CCR5拮抗剂是Aplaviroc(Demarest J.F.et al.2005.Update on Aplaviroc:An HIV Entry Inhibitor TargetingCCR5.Retrovirology 2(Suppl.1):S13)。在一些方面,CCR5拮抗剂是螺哌啶CCR5拮抗剂(Rotstein D.M.et al.2009.Spiropiperidine CCR5antagonists.Bioorganic&MedicinalChemistry Letters.19(18):5401...
(4)HEK293Tcellswereco-transfectedwithOTUB1andc-Mafplasmidsfor24hrs, followedbyWBanditshowedthatOTUB1upregulatedc-Mafprotein.Moreover,when MMcelllineRPMI-8226wasinfectedwithlentiviralOTUB1,c-MafinRPMI-8226cells werealsoincreased.WhencellsweretreatedwithCHX,aninhibitorofproteinsynthesis denovo,OTUB1markedly...
OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR J Biol Chem, 293 (13) (2018), pp. 4883-4892 CrossrefView in ScopusGoogle Scholar 23 T Goncharov, K Niessen, MC de Almagro, et al. OTUB1 modulates c-IAP1 stability to regulate sign...
JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells Activation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is the pivotal event in hepatic wound healing and fibrosis. Rat HSCs activate... DE Sm...
The present invention relates to a method for inhibiting the proliferation, survival and/or migration of a multiple myeloma cell that expresses (overexpresses) c-maf, comprising contacting the multiple myeloma cell with an effective amount of an inhibitor of expression and/or activity of c-maf, ...