C-type lectin-like CD161, a class II transmembrane protein, is a surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was expressed more frequently on gluten-reactive CD4+T cells compared to other memory CD4+T cells isolated from the same tissue compartment. CD161...
因此,有必要探讨乙肝肝硬化患者PVST的发生机制。 C型凝集素样受体2(C-type lectin-like receptor 2,CLEC-2)是一种II型跨膜受体,由位于12p13.31上的CLEC1B基因编码,分子量为32-40kDa(Martin EM, et al. Platelets. 2021; 32(6...
C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity. Eur J Immunol 1998;28:1134-1142....
【摘要】平足蛋白(podoplanin, PDPN)是广泛表达在多种肿瘤细胞中的Ⅰ型跨膜糖蛋白。C型凝集素受体2(C-type lectin-like receptor-2, CLEC-2)属于Ⅱ型跨膜糖蛋白,是近年来发现的一种新型血小板表面活化受体,是PDPN的内源性受体,两者结合后...
C-type-lectin-like domain CTLDcp: CTLD-containing protein DAS: distributed annotation system EMBP: eosinophil major basic protein EST: expressed sequence tag HMM: hidden Markov model MBP: mannose-binding protein Myr: million years NLSLH:
Importantly, in some cases, these novel C-type lectin-like lectins, encoded by genes from the same gene cluster, can act as receptor/ligand pairs, additionally contributing to the regulation of myeloid cell functions or their interaction with other (like NK) cell types. However, the relevance ...
Oncogene (2013) 32, 5449–5457; doi:10.1038/onc.2013.156; published online 6 May 2013 Keywords: Clec14a; C-type lectin-like domain; antibody; angiogenesis; endothelial cell; regulation INTRODUCTION The rapid recent development of recombinant antibody technol- ogy has produced B30 antibodies approved...
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively. CLEC-2 is expressed on the surface of platelets, which participates in...