Presently, the treatment of breast cancer still faces challenges due to recurrence and metastasis. The emergence of single-cell RNA sequencing (scRNA-seq) technology has brought new strategies to deeply understand the biological behaviors of breast cancer. By analyzing cell phenotypes and transcriptome ...
such as melanoma, lung cancer and colorectal cancer, scientists still focus on immune therapy and the immune microenvironment of BC, and the immune ecosystem within BC has been better elucidated recently with the advent of single-cell RNA-seq analysis...
Stratification of breast cancer (BC) into molecular subtypes by multigene expression assays is of demonstrated clinical utility. In principle, global RNA-sequencing (RNA-seq) should enable reconstructing existing transcriptional classifications of BC samples. Yet, it is not clear whether adaptation to ...
RNA-SeqofCirculatingTumorCellsinStageII–IIIBreast Cancer JulieE.Lang,MD 1 ,AlexanderRing,MD,PhD 2 ,TaniaPorras,MS 1 ,PushpinderKaur,PhD 1 ,VictoriaA.Forte, MD 3 ,NealMineyev,MD 1 ,DebuTripathy,MD 4 ,MichaelF.Press,MD,PhD 5 ,andDanielCampo,PhD ...
Bone morphogenetic protein 4 (BMP4) plays an important role in cancer pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line-dependent manner. To characterize the transcriptional mediators of these phenotypes, we performed RNA-seq and DNase-seq analyses after...
RNA-seq analysis reveals significant changes in the p52SHC tumor transcriptome To begin identifying gene networks that are mediated by p52SHC and p66SHC in breast cancer, RNA-seq was performed on mammary tumors derived from WT (n = 4), p52SHC-KO (n = 5), and p66SHC-KO (...
Breast Cancer is one of the most extensively researched cancers of the human body. This is has led to the creation and development of innumerable methods and techniques to control the growth and symptoms of the cancer way before it could cause any severe damage to other parts of the body. ...
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy. Immunotherapy is crucial for treating met
There is an increasing awareness of the importance of tumor – immune cell interactions to the evolution and therapy responses of breast cancer (BC). Not surprisingly, numerous studies are currently assessing the clinical value of immune modulation for BC patients. However, till now durable clinical...
Presently, the treatment of breast cancer still faces challenges due to recurrence and metastasis. The emergence of single-cell RNA sequencing (scRNA-seq) technology has brought new strategies to deeply understand the biological behaviors of breast cancer. By analyzing cell phenotypes and transcriptome ...