- 《Br J Cancer》 被引量: 672发表: 0年 ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of important non-coding RNAs in eukaryotes. ...
We previously reported that expression of an environmentally induced gene, mineral dust-induced gene (mdig), predicts overall survival in breast cancer patients. In the present report, we further demonstrate the differential roles of mdig between earlier
The Metastatic Breast Cancer Project is a patient driven project with RNA-seq data of 153 FFPE samples in total, including primary, local, and distant metastasis. TCGA counts data were downloaded from Firebrowse. SCAN-B data version 3 (StringTie FPKM Gene Data unadjusted) were downloaded from ...
Researchers have identified two microRNA that may predict which individuals with cancer are at elevated risk for COVID-19-related death. January 28, 2025 2 min read Save FDA expands Enhertu approval for breast cancer The FDA expanded the approval of trastuzumab deruxtecan...
RNA sequencing (RNAseq) data are from NCI's Genomic Data Commons (https://gdc.cancer.gov) and were analyzed with HTSeqGenie [16]. Gene expression was quantified as reads per kilobase of exon model per million mapped reads normalized by size factor (nRPKM), defined as the number of read...
Although recent studies have characterized the TME of breast cancer [17,18], there is still a lack of systematic research on the subtyping and functional definition of TAMs. Utilizing published scRNA-seq data from untreated primary breast cancer tissues, we conducted a detailed and biologically mean...
Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch signalling in breast cancer subtypes and in response to systemic therapy are largely lacking. A transcriptomic signa
RNA sequencing and western blot analysis were used to investigate the molecular mechanisms of RHBDD1. Results RHBDD1 was highly up-regulated in breast cancer tissue compared with that in normal tissue and associated with pathological tumor (pT) stage, pathological tumor-node-metastasis (pTNM) ...
Long non-coding RNAs (lncRNAs) involved in metabolism are recognized as significant factors in breast cancer (BC) progression. We constructed a novel prognostic signature for BC using metabolism-related lncRNAs and investigated their underlying mechanism
Breast cancer is one of the most common malignant tumors in women. It is a heterogeneous disease related to genetic and environmental factors. Presently, the treatment of breast cancer still faces challenges due to recurrence and metastasis. The emergence of single-cell RNA sequencing (scRNA-seq)...