Cancer cells within a tumour have heterogeneous phenotypes and exhibit dynamic plasticity. How to evaluate such heterogeneity and its impact on outcome and drug response is still unclear. Here, we transcriptionally profile 35,276 individual cells from 32 breast cancer cell lines to yield a single ce...
METHODS: The role and localisation of the Gln transporter SLC38A2/SNAT2 in response to Gln deprivation or pharmacological stresses was examined in a panel of breast cancer cell lines. Subsequently, the effect of SLC38A2 knockdown in Gln-sensitive cell lines was analysed. The prognostic value of...
1) breast cancer cell line 乳腺癌细胞株 1. Objective To explore the relationship of chemotherapy sensitivity and expression of multidrug resistance genes and apoptosis regulation genes in human breast cancer cell lines. 方法MTT法检测5株人乳腺癌细胞株Bcap37、MCF-7、T47D、MDA-MB-231和MDA-MB-...
Using this data, the researchers found substantial differences between lab-created breast cancer cell lines and actual advanced, or metastatic, breast cancer tumor samples. Surprisingly, MDA-MB-231, a cancer cell line used in nearly all metastatic breast cancer research, showed little genomic similari...
2.The aim of this study was to investigate the expression and correlation of estrogen receptor-α(ER-α)and thyroid hormone receptor-β(TR-β)in breast cancer cell lines,and to determine the changes of relevant receptors expression and its possible mechanism due to T3 treatment.本实验目的是研究...
The phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study using only primary tumor tissue. We embarked on this study hypothesizing that breast cancer cell lines would contain analogous ...
1) breast cancer cell lines 乳腺肿瘤细胞系2) the canine breast tumor cell 犬乳腺肿瘤细胞 1. But the apoptosis mechanism of the canine breast tumor cell induced by the Paclitaxel has not a perfect explanation at present, this experiment has conducted a series of studies on this question. ...
The phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study using only primary tumor tissue. We embarked on this study hypothesizing that breast cancer cell lines would contain analogous ...
Current xenograft models of breast carcinoma involve murine or human breast cancer cell lines implanted into the mammary fat pad of mice or injected systemically by intravenous or intracardiac routes. Tumor cells injected into the mammary tissue yield reproducible tumors, but can require weeks to ...
The majority of breast cancer research is conducted using established breast cancer cell lines as in vitro models. An alternative is to use cultures established from primary breast tumours. Here, we discuss the pros and cons of using both of these models in translational breast cancer research.关...