associated with invasion and metastasis, as is the case with CD5856. Furthermore, the differences in the mutation profiles among subtypes underscore the complexity of this disease and the need for specific therapeutic approaches. In the Basal A subtype of breast cancer, a predominance of mutations ...
SubtypeselectivityPhytoestrogensBreastcancerEstrogen signaling is mediated by two estrogen receptors (ERs), ERα and ERβ, which have unique roles in the regulation of breast cancer cell proliferation. ERα induces proliferation in response to estrogen and ERβ inhibits proliferation in breast cancer ...
Furthermore, CD44+/CD24-/ESA+ cells can self-renew, reconstitute the parental cell line, retain BrdU label, and preferentially survive chemotherapy. Conclusion These data validate the use of cancer cell lines as models for the development and testing of novel therapeutics aimed at eradicating ...
(PHGDH). A previous screen showed its importance to breast cancer cell growth32. Interestingly, that screen was performed in MCF10DCIS cells, which is a TN cell line. In agreement,PHGDHmRNA was found to be a marker of basal tumours as a part of the PAM50 signature. Thus our results ...
(a) Luminal, basal or mixed cell morphology can be predicted based on CD44 and CD24 expression. Provided are representative flow cytometry dot plots of CD44 and CD24 expression adjacent to phase-contrast brightfield images of each cell line subtype. Cell lines are composed of luminal-like, CD...
. As only one replicate per cell line had been analysed per treatment and timepoint, differential expression analysis was performed by fitting linear models with limma [53] and cell culture condition, timepoint, cell line subtype and library preparation batch as model covariates. Breast cancer ...
Expression profiling studies [11, 64] have also suggested that ERBB2-amplified BCs constitute a heterogeneous group that could be subdivided according to ER status: ER+ ERBB2-amplified BCs fall into the luminal B cluster; and ER- ERBB2-amplified BCs constitute the actual ERBB2-like subtype. ...
the luminal subtype exhibits a preference for bone metastasis, while triple-negative breast cancer (TNBC) generally tends toward visceral metastasis. Notably, regardless of the ultimate target, the initial stages of the cancer metastasis cascade share similarities across many types of cancer [5]. A ...
"This suggested a possible link between CBX2 activity and breast cancer, but the nature of that link hadn't been investigated," she said. "So we switched off the gene in a human breast cancer cell line and this slowed down the growth of those cancer cells, suggesting that CBX2 might ...
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 12, R68 (2010). Article PubMed PubMed Central Google Scholar Cortes, J. et al. Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. N. Engl. J. Med. 387...