Breast Cancer Research & TreatmentCalaf G, Abarca-Quinones J, Feuilhade F, Beaune J, Dupre G, Orrico M, Barnabas-Sohi N, Kouyoumdjian JC: New cell lines of human breast cancer origin. Breast Cancer Res Treat 21: 63–75, 1992
as shown in Fig.1A. In the atlas, it is possible to recognize a luminal-supergroup with intermixing of cells from different luminal cell lines and Her2-enriched (Her2+) cell lines, while triple-negative breast cancer (TNBC) cell lines form distinct clusters, thus suggesting that these represen...
es and uses thereof Novel breast cancer cell lines and uses thereofNovel breast cancer cell lines and uses thereof
Using this data, the researchers found substantial differences between lab-created breast cancer cell lines and actual advanced, or metastatic, breast cancer tumor samples. Surprisingly, MDA-MB-231, a cancer cell line used in nearly all metastatic breast cancer research, showed little genomic similari...
Cell lines are widely-used models to study metastatic cancer although the extent to which they recapitulate the disease in patients remains unknown. The recent accumulation of genomic data provides an unprecedented opportunity to evaluate the utility of
The phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study using only primary tumor tissue. We embarked on this study hypothesizing that brea
The phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study using only primary tumor tissue. We embarked on this study hypothesizing that breast cancer cell lines would contain analogous ...
The majority of breast cancer research is conducted using established breast cancer cell lines as in vitro models. An alternative is to use cultures established from primary breast tumours. Here, we discuss the pros and cons of using both of these models
Recent advances proposed a new molecular taxonomy of breast cancer that defines molecular subtypes such as luminal or basal-like cancers. Hopefully this may modify breast cancer management. A great part of our knowledge on breast carcinomas is based on studies of breast cancer cell lines (BCC)....
Compared with the findings in the human breast cancer lines, which suggest an association between the PR-status and hGH-N expression, the results from in the prostate cancer cell lines seem contradictory. On the basis of composite response elements for the PR and the AR, AR+ prostate cancer ...