HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive casesHER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive casesTargeti...
et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2, 127–137 (2002). Article CAS Google Scholar Lee-Hoeflich, S. T. et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res. 68,...
Hormone receptor status does not affect the clinical benefit of trastuzumab therapy for patients with metastatic breast cancer Clin Breast Cancer, 6 (2005), pp. 247-252 View in ScopusGoogle Scholar [12] G. Arpino, H. Weiss, A.V. Lee, R. Schiff, S. De Placido, C.K. Osborne, et al...
2C) does not alter the phosphorylation of ERK (Fig. 4B). These data suggest that ErbB2-induced aggregation during ECM-detachment can facilitate the activation of ERK to block anoikis. We were able to extend these findings to the aforementioned breast cancer cell lines. Methylcellulose treatment...
In addition, our study shows that in combination, PEITC can significantly enhance the apoptosis-inducing effects of doxorubicin. Our study provides a direction towards the mechanism of HER2-mediated sensitivity of cells to chemotherapy. Methods Cell culture Human breast carcinoma cell lines MCF-7 and...
In 2020, trastuzumab deruxtecan (T-DXd) was the second approved ADC for patients who had received at least 2 lines of anti-HER2-based therapy in the metastatic setting. The success of these two agents has transformed the treatment of HER2-positive breast cancer and has re-energized the ...
(yes vs no) 0.434 aALN axillary lymph node bPgR progesterone cThe cutoff values of Ki-67 are 14 % in NCC and 10 % in SNUH [26] metastasis and large tumor size (p < 0.001, p = 0.038, respectively), and local recurrence or contralateral breast recurrence was associated with only ...
Similarly, a recent study also reported that miR-550a-3-5p could directly target YAP to exert tumor-suppressor roles in various cancers containing colon cancer, breast cancer, lung cancer, and head and neck cancer [55]. However, this didn’t include OSCC cell lines and only concentrated on...
Quantification of ALDH-positive cells in each breast cell line is shown (bottom). Error bars indicate the s.d. from three experiments. (c) FACS for SP cells in MCF10A and breast cancer cell lines. (d) MCF-10A and MCF-10A-neu cells were stained with BODIPY and analyzed with ALDH-...
In that respect, Korkaya et al (2008) demonstrated that trastuzumab efficacy was directly associated with its effect on the BCSC subpopulation by showing that the drug decreased the ALDEFLUOR-positive population in trastuzumab-sensitive HER2-positive breast cancer cell lines. Moreover, Li et al (...