Apoptosis/Necrosis Induction by Ultraviolet, in ER Positive and ER Negative Breast Cancer Cell Lines. Iran J Cancer Prev. 2015;8(6):e4193. doi: 10.17795/ijcp-4193. [PubMed: 26855725].Shokrollahi Barough M, Hasanzadeh H, Barati M, Pak F, Kokhaei P, Rezaei-Tavirani M. Apoptosis/...
Anastrozole is commonly used for the treatment of oestrogen receptor (ER)-positive breast cancer but can increase thromboembolic risk. It is unclear if ER presentation is associated with platelet-mediated hypercoagulation. We i...
The expression of ESR1 in ER positive breast cancer cells was reported to be associated with a distal super enhancer7, which localised in the same topologically associating domain (TAD) with ESR1 gene (Supplementary Fig. 5a) and characterised by high H3K27Ac, high H3K4me1, low H3K27me3 an...
We examined the activity of capsaicin on breast cancer cells in vitro and in vivo. The drug potently inhibited growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, which was associated with G0/G1 cell-cycle arrest, increased ...
C.D.; Verardo, R.; Di Leo, A.; Migliaccio, I. A Gene Expression Signature of Retinoblastoma Loss-of-Function Is a Predictive Biomarker of Resistance to Palbociclib in Breast Cancer Cell Lines and Is Prognostic in Patients with...
27HC also stimulated proliferation in three other ER+ breast cancer cell lines, HCC1428, T47D, and ZR75, indicating that the response is not unique to MCF-7 cells (Figure S2). MCF-7 cells express both ERα and liver X receptors (LXR) (DuSell et al., 2008, El Roz et al., 2012...
Tamoxifen, an endocrine therapy drug used to treat breast cancer, is designed to interrupt estrogen signaling by blocking the estrogen receptor (ER). However, many ER-positive patients are low reactive or resistant to tamoxifen. Metformin is a widely use
BMC Cancer (2018) 18:99 DOI 10.1186/s12885-018-3993-6 RESEARCH ARTICLE Open Access Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway Inamul Haque1,2†, Arnab Ghosh1,2†, Seth Acup1, ...
C.D.; Verardo, R.; Di Leo, A.; Migliaccio, I. A Gene Expression Signature of Retinoblastoma Loss-of-Function Is a Predictive Biomarker of Resistance to Palbociclib in Breast Cancer Cell Lines and Is Prognostic in Patients with ER Positive Early Breast Cancer. Oncotarget 2016, 7, 68012–68...
proliferation of MDA-MB-231 cellsin vitroandin vivo. ERα induces cell proliferation by increasing the expression of MYC and cyclin D1 (refs33,34). Therefore, ERα has been used as a key target for endocrine therapy of ERα-positive breast cancer to block the proliferation of cancer cells...