Molecular CancerSun, Y., Wang, Y., Fan, C., Gao, P., Wang, X., Wei, G., Wei, J., 2014. Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 ac- tivation. Mol. Cancer 13, 137-137.
I. A Gene Expression Signature of Retinoblastoma Loss-of-Function Is a Predictive Biomarker of Resistance to Palbociclib in Breast Cancer Cell Lines and Is Prognostic in Patients with ER Positive Early Breast Cancer. Oncotarget 2016
These results show that, while mutations in theestrogen receptoritself are a common cause of resistance to hormonal therapy in metastatic ER-positive breast cancer, mutations in other genes and proteins can drive treatment resistance. The scientists tested a strategy aimed at blocking the effects of ...
In addition, in breast cancer cells, PAK4 promotes migration and invasion by activating CEBPB [9]. Likewise, nuclear PAK4 represses the expression of LIFR to promote the bone metastasis of ER positive breast cancer cells [10]. Although this study has suggested that nuclear PAK4 modulates ...
We first had to choose an appropriate cell line in which to carry out the assays. Cell transfection efficiency, convenience, and cost were each taken into account. The ERα positive breast cancer cell lines MCF7 and T47D are frequently used to study the influence of genes on the function ...
Physiological levels of soy isoflavones inhibit the growth of oestrogen receptor β-positive but not α-positive breast cancer cells The biphasic effect of soy isoflavones (genistein and daidzein) on oestrogen receptor (ER)α+ breast cancer cell proliferation is well documented, with con... J Walla...
ER positive breast tumours are associated with tailored therapeutic approaches81,82, which increase the risk for thromboembolic complications. Our results highlight the procoagulant nature of breast cancer cells themselves and substantiate clinical studies indicating that Tamoxifen, regardless of model used,...
Allred, D. C., Brown, P. & Medina, D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer.Breast Cancer Res.6, 240–245 (2004). CASPubMedPubMed CentralGoogle Scholar Lin, X., Xiang, H. & Luo, G. Targeting estrogen receptor alpha ...
We examined the activity of capsaicin on breast cancer cells in vitro and in vivo. The drug potently inhibited growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, which was associated with G(0)/G(1) cell-cycle arrest, ...
Moreover, STAT1 signaling, necessary for CIITA pIV activation, and selected STAT1 regulated genes were variably downregulated by E2 in transfected and endogenous ERα positive breast cancer cells, whereas STAT1 signaling was noticeably augmented in ERα breast cancer cells. Collectively, these results ...