Testing for germlineBRCA1/2 mutations has an established predictive role in breast cancer risk assessment. More recently, studies have also identifiedBRCA1/2 status as clinically relevant in the selection of therapy for patients already diagnosed with breast cancer. Emerging breast and ovarian cancer ...
Several barriers to genetic testing exist, including limited access to testing facilities, trained counselors, and psychosocial support, as well as the financial burden of testing. Here, we describe current implications of gBRCAm testing for patients with breast cancer, summarize current approaches to ...
One of the most famous of them is actressAngelina Jolie, who proactively underwent a double mastectomy and oophorectomy, or ovary removal, to minimize her cancer risk after testing positive for the BRCA1 gene mutation. Jolie’s story raised awareness of BRCA testing, but it also created contro...
Trainer AH, Lewis CR, Tucker K, Meiser B, Friedlander M, Ward RL (2010) The role of BRCA mutation testing in determining breast cancer therapy. Nat Rev Clin Oncol 7(12):708–717Alison H.Trainer, Craig R.Lewis, KathyTucker, BettinaMeiser, MichaelFriedlander, Robyn L.Ward. (2010) The ...
Germline BRCA mutations (BRCAm) strongly influence the risk of developing breast cancer. This study aimed to understand the role of BRCAm testing in affect
AlthoughBRCAmutation testing in all women with breast cancer younger than 50 could prevent the highest number of breast and ovarian cancers, the cost-effectiveness associated with this approach was unfavorable. However, testing women with triple-negative breast cancers younger than 50 proved to be ...
We investigated the barriers to and promoters of takingBRCAtesting, after the start of national healthcare insurance coverage for non-metastatic breast can... T Taji,N Odan,Y Kataoka,... - 《Breast Cancer》 被引量: 0发表: 2022年 Utilization of BRCA testing in older women with breast cance...
Most women know about mammograms for early detection of breast cancer. The BRCA1 and BRCA2 genetic tests are much less widely known. Dr. Douglas E.
In this study, we evaluated factors associated with the decision to undergo BRCA1/BRCA2 gene testing at the time of initial breast cancer diagnosis... Schwartz,D M. - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the...
Patients with a higher likelihood to develop BRCA 1 or BRCA 2 mutations are slipping through the cracks, making testing for these mutations a vital part of any breast cancer treatment plan. It’s important for their providers to test for BRCA1 and BRCA2 gene mutations in patients with...