Purpose/Objective(s): Based on existing literature, BRCA gene muta- tions are present in over 10% of all breast cancers. Since germ line BRCA mutations are inherited in an autosomal dominant fashion, the identifica- tion of a positive genetic mutation in an index case, warrants screening of ...
Screening recommendations for women with BRCA mutations include annual breast MRI starting at age 25, with annual mammogram added at age 30. The median age
Abstract P3-02-03: Breast cancer screening by women from BRCA1 & BRCA2 mutation positive families: Purpose: Breast screening may detect breast cancer (BC) at an early stage but optimal screening depends on a woman's level of risk and age. This study estimates the contemporary prevalence of ...
screening and preventioncase studiesdecision makingfeminismgeneticslived experiencewomen’s healthLittle is known about how the breast cancer (BRCA) gene mutation affects women’s decision-making processes. I use a feminist standpoint lens to explore the process by which BRCA-positive women came to ...
Gibson I, et al. Real-world outcomes in patients with HR-positive/HER2-negative metastatic breast cancer and germline/tumour BRCA mutations receiving 1st-line CDK4/6 inhibitors plus endocrine therap[EB/OL]. [2024-09-11...
BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-mutated BC are estrogen receptor (ER)-positive, which is a particular type...
64% of the BRCA1 mutation carriers had ER- negative breast cancers and 90% of the BRCA2 carriers had ER-positive breast cancers (Table 4). Only 4 of 42 mutations found among women with an ER-positive breast cancer were in BRCA1 (9.5%). Among the 791 patients diagnosed at 50 years ...
From the set-up of a screening program of breast cancer patients to the identification of the first BRCA mutation in the DR Congo. BMC Public Health. 2014;14:759.Luyeye Mvila G, et al. From the set-up of a screening program of breast cancer patients to the identification of the first...
of false-positive breast and ovarian cancer screening test results on perceived cancer risk and cancer worry, and (b) the joint effects of FPTR, risk perceptions, and worry on the choice of risk-reducing surgery among BRCA1/2 mutation carriers undergoing an intensive cancer screening protocol. ...
Annual breast magnetic resonance imaging (MRI) plus mammography is the standard of care for screening women with inherited BRCA1/2 mutations. However, long-term breast cancer-related mortality with screening is unknown. Between 1997 and June 2011, 489 previously unaffected BRCA1/2 mutation carriers...