Several barriers to genetic testing exist, including limited access to testing facilities, trained counselors, and psychosocial support, as well as the financial burden of testing. Here, we describe current implications of gBRCAm testing for patients with breast cancer, summarize current approaches to ...
Testing for germlineBRCA1/2 mutations has an established predictive role in breast cancer risk assessment. More recently, studies have also identifiedBRCA1/2 status as clinically relevant in the selection of therapy for patients already diagnosed with breast cancer. Emerging breast and ovarian cancer ...
参考资料: [1] https://www.targetedonc.com/view/mediola-highlights-importance-of-brca-testing-in-advanced-ovarian-cancer [2] Daly M B,Pilarski R,Berry M, et al. NCCN guidelines insights: Genetic/familial high-risk assessment: breast and ovarian...
One of the most famous of them is actressAngelina Jolie, who proactively underwent a double mastectomy and oophorectomy, or ovary removal, to minimize her cancer risk after testing positive for the BRCA1 gene mutation. Jolie’s story raised awareness of BRCA testing, but it also created contro...
14. Jeanna Wallenta Law, Law JW,et al. Exploring racial disparities in BRCA testing for triple negative breast cancer patients: A real-world data analysis. 2021 SABCS, P3-14-17. 15. Jiang YZ, et al. Molecular subt...
BRCA基因,全称“乳腺癌易感基因”(Breast Cancer Gene),包括两个基因:BRCA1和BRCA2,分别位于人类染色体17q21上和13q12上,是与卵巢癌和乳腺癌发生密切相关的抑癌基因,就像体内细胞的“修理工”,能生产肿瘤抑制蛋白,专门负责修复损伤的双链DNA,细胞周期调控等,并及时修复“生病”的细胞,避免其进一步发展为肿瘤细胞。
[1]Armstrong K, Weiner J, Weber B, Asch DA. Early adoption of BRCA1/2 testing: who and why. Genet Med. 2003;5(2):92-98. doi:10.1097/01.GIM.0000056829.76915.2A [2]Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1...
Scuffham, PhD1,2 Purpose: To evaluate the cost-effectiveness of BRCA testing in women with breast cancer, and cascade testing in family members of BRCA mutation carriers. Methods: A cost-effectiveness analysis was conducted using a cohort Markov model from a health-payer perspective. The model ...
[1]Armstrong K, Weiner J, Weber B, Asch DA. Early adoption of BRCA1/2 testing: who and why. Genet Med. 2003;5(2):92-98. doi:10.1097/01.GIM.0000056829.76915.2A [2]Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1...
Breast Cancer BRCA mutation testing can reveal important information about potential treatment options along with patient and familial risk. Discover more Prostate Cancer The ability to investigate, diagnose and manage prostate cancer has been improved significantly by the identification of mutations in BRCA...