Germline mutations inBRCA1 orBRCA2 (gBRCA1/2m) confer a well-established increased risk for the development of papillary serous ovarian cancer (OC), triple-negative breast cancer (TNBC;BRCA1), oestrogen receptor (ER)-positive breast cancer (BC), and human epidermal growth factor receptor 2 (...
Getting tested seemed like a wise choice for 39-year-old Carrie Berenstein, whose mother developed cancer in her early 30s, and whose father died of cancer at 57. “My mother was scared," she said, “because it seemed like everyone in the family was getting cancer young, and thought it ...
The U.S. Food and Drug Administration today authorized the Personal Genome Service Genetic Health Risk (GHR) Report for BRCA1/BRCA2 (Selected Variants). It is the first direct-to-consumer (DTC) test to report on three specific BRCA1/BRCA2 breast cancer gene mutations that are most common ...
Carrying a BRCA1/2 gene mutation increases one's life- time risk of developing breast and/or ovarian cancer compared with the general population.1 The most noted benefits of test- ing for mutations are: (1) to obtain breast cancer risk informa- tion for one's self and family members, ...
Which Patients Do We Need to Test for BRCA1/2 Mutation? Feasibility of Adjuvant Olaparib Treatment in Early Breast Cancer–Real-World Data from Two Large German Breast Centers. Cancers 2023, 15, 3847. doi.org/10.3390/cancers发布于 2023-11-09 11:20・IP 属地江苏...
screening test、population screening、BRCAscreening、cancer risk assessment、cancer susceptibility、genome sequencing、variant classification、genetic counseling、quality assurance、practice guideline;中文文献检索词主要包括乳腺癌易感基因、遗...
Pal T, Permuth-Wey J, Betts JA, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005;104(12):2807-2816. Antoniou A, Pharoah PD, Narod S, et al. Average risks of breast and ovarian c...
Consumer Test for BRCA1/BRCA2 Mutations in Breast Cancerdoi:10.1097/01.COT.0000532232.59732.f3Oncology Times
Patients with a higher likelihood to develop BRCA 1 or BRCA 2 mutations are slipping through the cracks, making testing for these mutations a vital part of any breast cancer treatment plan. It’s important for their providers to test for BRCA1 and BRCA2 gene mutations in patients with...
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