Background: Triple‐negative breast cancer (TNBC) is the neoplasia most associated with BRCA1 germline pathogenic variants (PV) and is more likely to develop metastases than the other breast cancer (BC) subtypes, mainly in the lungs and the central nervous system (CNS). Recently, ...
此为记! 初夏时节,肿瘤外科的年轻人们阅读分享文献的热情不减,今天和我们分享文献的是我们的魏群博士,分享的文献是“Carboplatin in BRCA1/2-mutated and triple negative breast cancer BRCAness subgroups: the TNT Trial”,发表于2018年5月N...
三阴性乳腺癌(triple-negative breast cancer,TNBC)的BRCA1/2基因突变率约为12%[37],激素受体(hormone receptor)阳性/人表皮生长因子受体2(human epidermal growth factor receptor2,HER-2)阴性的乳腺癌BRCA1/2基因突变率为4%[38]。...
参考文献 Hahnen E, Lederer B, Hauke J, et al.Germline Mutation Status, Pathological Complete Response, and Disease-Free Survival in Triple-Negative Breast Cancer: Secondary Analysis of the GeparSixto Randomized Clinical Trial.JAMA Oncol. 2017 Jul 13. doi: 10.1001/jamaoncol.2017.1007. [Epub ahea...
Promoter methylation of BRCA1 in triple-negative breast cancer predicts sensitivity to adjuvant chemotherapy. Ann. Oncol. 24, 1498–1505 (2013). Article CAS PubMed Google Scholar Esteller, M. et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J. Natl...
Triple-negative breast cancers (TNBC) lack expression of oestrogen, progesterone and HER2 receptors. The gene expression profiles of TNBCs are similar t... MW Wong-Brown,CJ Meldrum,JE Carpenter,... - 《Breast Cancer Research & Treatment》 被引量: 64发表: 2015年 BRCA1/2 mutations and tripl...
[translate] atake care of it. 作为关心它。 [translate] aRelative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast cancer in Ashkenazi Women. BRCA1和BRCA2变化的相对贡献对“三倍消极”乳腺癌在Ashkenazi妇女。 [translate] ...
Breast-conserving surgery IBTR: Ipsilateral breast tumor recurrence NP: New primary tumor TR: True local recurrence BCT: Breast-conserving therapy BCSS: Breast cancer-specific survival OS: Overall survival PFS: Progression-free survival TNBC: Triple-negative breast cancer ORR: Overall re...
Am J Cancer Res. 2015;5(7):2113-26.Ollier M, Radosevic-Robin N, Kwiatkowski F, Ponelle F, Viala S, Privat M et al (2015) DNA repair genes implicated in triple negative familial non-BRCA1/2 breast cancer predisposition. Am J Cancer Res. 5(7):2113-2126...
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA Authors - Limei Ji View Article human WB Pharmacol Res FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathway...