Life Expectancy Gains From Secondary Cancer-Prevention Strategies for BRCA1- and BRCA2-Positive Women With Early-Stage Breast Cancer* Impact of Variation in Base-Case Probabilities on Life Expectancy Gains for 30-Year-Old Women With Moderate-Penetrance BRCA1 and BRCA2 Mutations and Node-Negative ...
In the context of a known familial mutation, both positive and negative predictive genetic test results are interpretable and informative. Given the high risks of breast and ovarian cancer that are associated with BRCA1 and BRCA2, and the availability of proven risk reduc- tion strategies, the ...
Decision analysis of prophylactic mastectomy and oophorectomy in BRCA1-positive or BRCA2-positive patients. Young Ashkenazi Jewish women or those from high-risk families who test positive for BRCA1 or BRCA2 mutant genes have a significant risk of developing breas... VR Grann,KS Panageas,W Whan...
Alternating DM/MRI starting at age 25 years also produced the highest number of false-positive screens per woman (BRCA1, 4.5 BRCA2, 8.1).CONCLUSIONS:Annual MRI at age 25 years/delayed alternating DM at age 30 years is probably the most effective screening strategy in BRCA mutation carriers. ...
Emerging data suggest that BRCA1-related breast cancers are more likely than sporadic tumors to be derived from the basal epithelial layer of cells of the mammary gland, to be triple negative and to stain positive for CK5/6 markers.95–97 Information regarding BRCA2-related breast tu- mors ...
Both prophylactic surgery and IS have positive and negative short- and long-term consequences for women. In our model, we implemented short-term consequences of the surgery itself by quality-of-life reduction (disutility) due to surgery and assumed women to recover from surgery in the following...
Moreover, antidrug antibody assays will be done and reported as either positive or negative. References Wu L, Wang J, Li G, et al. A phase 1b/II clinical study of AK112, a PD-1/VEGF bispecific antibody, in combination with olaparib in BRCA germline wild-type platinum sensi...
cancer than noncarriers. Primary bilateral mastectomy could also be considered and discussed with these patients. Breast tumors fromBRCA1mutation carriers are predominantly of basal subtype (i.e., triple negative), andBRCA2mutation carriers are of luminal subtype (i.e., estrogen receptor positive)....
Probability, probability of ovarian cancer occurrence (negative numbers mean lower with screening); LE, life expectancy in years; QALE, quality-adjusted life expectancy in years (positive numbers mean higher with screening); DCOST, discounted cost at a rate of 3% per year (positive numbers mean ...
Selected studies indirectly accounted for adverse effects on health outcomes through reduced quality of life following events such as prophylactic surgery21,23,28–31 or false-positive screening tests.45,48 GENETICS in MEDICINE | Volume 20 | Number 10 | October 2018 1147 SYSTEMATIC REVIEW PETELIN ...