D. et al. Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma. Cancer 98, 1569–1577 (2003). PubMed Google Scholar Goffin, J. R. et al. Impact of germline BRCA1 mutations and overexpression of p53 on prognosis...
and thus their foci formation is present in HR-proficient cells, whereas γH2AX and 53BP1 as conventional DNA damage markers build foci in HR-deficient cells [58]. Interestingly, researchers proved that the positive BRCA1 and RAD51 foci formation is associated with non-response to olaparib ther...
Kimberly L. Blackwell, MD:And I just would put in a plug because there is a phase III study that will look at the addition of that PARP inhibitor. But there are lots of PARP inhibitors out there for BRCA mutation carriers. And what I’m seeing in my referral patterns is people, when...
++ Multiple studies and the predominance of the evidence are positive. + May be an association, predominantly single studies; smaller limited studies and/or inconsistent but weighted toward positive. BRCA and Fertility Women in general, and particularly women with cancer, face many challenges when ...
HDR capacity is expressed as the percentage GFP positive cells relative to the GFP positive population in wild type (WT) BRCA2 samples. Error bars indicate the SD of six independent GFP measurements per variant. The HDR capacity was measured for all variants that were able to complement the ...
[37]. Therefore, 42 different pathogenic point mutations inBRCAwere described in the cohorts A, B and C in Brazil. All patients positive forBRCAmutations had a family history of BC (Additional file1: Table S1; Tables1,2). Four different LGRs (3 inBRCA1and 1 inBRCA2) were also ...
Increasing attention has been paid to the relevance of testing for men within BRCA1/2-positive families given that such testing may provide important information about their cancer risks, particularly for prostate cancer, and risks to their offspring. However, men are much less likely to seek ...
Its initiative to facilitate NIH-funded research on the BRCA genes, its financial assistance program to improve patients' access to tests and media portrayal of the company as an American success story have likely had a positive impact on popular perception (So and Joly 2013). The strong ...
28/45 24/42 3/44 1/43 29/46 11/46 2/46 0.506 0.057 0.034 0.027 0.281 0.097 0.140 0.742 0.508 0.631 0.594 0.383 0.411 0.156 0.696 0.851 0.857 0.680 0.631 0.012b aThe number of immunohistochemistry (IHC) positive cases are shown as the numerator over the number of cases tested by IHC....
Here, we identify the ubiquitin-specific protease USP21 as a positive regulator of BRCA2, a key mediator of DNA repair by homologous recombination. USP21 interacts with, deubiquitinates and stabilizes BRCA2 to promote efficient RAD51 loading at DNA double-strand breaks. As a result, depletion ...