8.Byrski T, Gronwald J, Huzarski T, et al: Path- ologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 28:375-379, 2010 9.Byrski T, Huzarski...
Clinical features of BRCA1/BRCA2 positive hereditary breast cancersdoi:10.1016/S1359-6349(08)70452-XR.CoutoandA.PeixotoandT.SarmentoandC.SDOSEuropean Journal of Cancer Supplements
所有患者在一线化疗开始时已知BRCA1/2胚系突变状态,一线含铂化疗方案可以显著改善BRCA1/2胚系突变患者(n=300)的无进展生存期(HR=0.54,95%CI:0.4～0.73;P<0.001)和总生存期(HR=0.70,95%CI:0.49～0.99;P=0.047),特别是在激素受...
Results: Of the 287 breast cancers, 66 cases were BRCA1 mutation positive, 47 cases were BRCA2 mutation positive and 174 cases were BRCA1/2 mutation negative. BRCA1 mutation breast cancer had higher nuclear grade tumors than the other two groups (P<0.001), 72.7% of BRCA1 mutation breast ...
The numbers of p27+ cells are also significantly decreased in control parous women, the majority of these cells are estrogen receptor (ER+) and phospho-Smad2 (pSmad2+) positive, and their numbers inversely correlate with ovarian hormone-induced proliferation during the menstrual cycle and ...
Recent evidence suggests that unidentified BRCA1/2 variations or other genetic events may contribute to familial ovarian cancers. Allelic imbalance (AI) of BRCA1/2 expression, a result of a significant decrease in the ratios between the expression from one allele of BRCA1/2 and the other allele...
24,25BRCA2 carriers are more likely to develop estrogen receptor–positive cancers, so their lower contralateral breast cancer risk estimates may in part be due to greater use of endocrine therapy. Hormone and chemotherapeutic treatments were not considered, so the present estimates represent risks ...
A significant number of cancers of the buccal cavity and pharynx were also observed in a study examining a large series of BRCA2 families from North America and Europe (RR=2.26; P=0.03) [69]. Cancers of the throat and oral cavity were also observed in BRCA2 carriers in three out of ...
BRCA亚组分析显示:对于BRCA1患者,激素受体状态对预后影响较小;对于BRCA2患者,HR+患者在前5年内预后更好,之后BCSS方面预后较差,5年后的aHR为2.23。 肿瘤亚型分析结果 在符合本次分析条件的4363名BRCA年轻患者中,612名(14.0%)为管腔A型,1038名...
Both breast cancers were consistent with stage I invasive ductal carcinomas. Colonoscopy during an investigation for hematochezia revealed a 2-cm ulceration in the terminal ileum 22 months later, and microscopic examination of a biopsy specimen of the ulceration revealed a poorly differentiated mass...