乳腺癌易感基因(breast cancer susceptibility gene, BRCA)与乳腺癌有着密不可分的关系。BRCA基因的两个成员,即BRCA1和2,分别是在1990年和1994年被分离。 乳腺癌可以分为遗传性乳腺癌和散发性乳腺癌(sporadic breast cancer),散发性乳腺癌指的是没有发现明确的遗传基因改变(完整的癌变点)与乳腺癌家族史的乳腺癌...
BCS aims to remove the breast tumor, with clear margins, in a manner that is cosmetically acceptable to the patient16. Although BCS is recommended for most patients with early-stage operable breast cancer15, the best approach for patients harboring gBRCAm is unclear. Practice guidelines recommend ...
(Geyer C E, Sikov W M, Huober J, et al. Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial[J]. Annals of Oncology, 20...
BRCA in breast cancer: ESMO Clinical Practice Guidelines. Ann Oncol. 2011; 22 Suppl 6:vi31-4. https://doi.org/10.1093/annonc/mdr373 PMID: 21908500.Balmana J, Diez O, Rubio IT, et al: BRCA in breast cancer: ESMO Clinical Practice Guidelines. Ann Oncol 22 Suppl 6:vi31-4, 2011...
2022年10月28日,来自以色列耶路撒冷Shaare Zedek癌症中心的Benjamin W. Corn在Journal of Clinical Oncology发表了题为“Nonsurgical Options for Risk Reduction of Contralateral Breast Cancer in BRCA Mutation Carriers With Early-Stage...
Myers SP, Sevilimedu V, Barrio AV, Tadros AB, Mamtani A, Robson ME, Morrow M, Lee MK. Pathologic complete response after neoadjuvant systemic therapy for breast cancer in BRCA mutation carriers and noncarriers. NPJ Breast Cancer. 2024 Jul 26;10(1):63. doi: 10.1038/s41523-024-00674-y...
Loss of BRCA1 p220 function often results in basal-like breast cancer (BLBC), but the underlying disease mechanism is largely opaque. In mammary epithelial cells (MECs), BRCA1 interacts with multiple proteins, including NUMB and HES1, to form complexes that participate in interstrand crosslink ...
[4]Fasching PA, Link T, Hauke J, et al. Neoadjuvant paclitaxel/olaparib in comparison to paclitaxel/carboplatinum in patients with HER2-negative breast cancer and homologous recombination deficiency (GeparOLAstudy)[J]. Ann ...
[5]Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst. 1999;91(15):1310-1316. doi:10.1093/jnci/91.15.1310 [6]Johannsson O, Loman N, Möller T, Kristoffersson U, Borg A, Olsson H. Incidence of malignant tumours in relatives of BRCA1 and BRCA...
近日,由意大利热那亚大学 Matteo Lambertini 领衔的研究团队,联合全球 78 个研究中心,在顶级医学期刊 JAMA(IF:120.7)上发表题为 「Pregnancy After Breast Cancer in Young BRCA Carriers An International Hospital-Based Cohort Study」 的文章。这是首次对携带 BRCA 胚系致病突变的年轻女性乳腺癌患者的妊娠和生存结局...