Breast Cancer Susceptibility Gene1 (BRCA1) is a tumor suppressor gene for breast and ovarian cancers. The gene locates at chromosome 17q21 and encodes for 1863 amino acids protein. It is believed that BRCA1 protein is involved in many functions such as DNA repair, centrosome replication, cell...
(“How a Breast Cancer Gene May Affect Alzheimer’s” By Alice Park. Nov. 30th, 2015.Time.) 词汇短语 1*. BRCA1 乳腺癌1号基因 2*. mutate ['mjutet] v 变化,产生突变 3*. Alzheimer ['ælz'ɛmɚ] n. 阿...
" BRCA1: More than a hereditary breast cancer gene? " Nature Genetics 9:335-336.Boyd J. BRCA1:More than a hereditary breast cancer gene[J].Nature Genetics,1995,(04):335-336.doi:10.1038/ng0495-335.Boyd, J. . BRCA1: more than a hereditary breast cancer gene? Nature (Genet.) , 9...
To the Editor: A family history of breast and/or ovarian cancer is associated with an increased chance of carrying a mutation in the BRCA1 or BRCA2 gene. N... R Kaldate,A Huston,H Mccoy,... - 《Breast Journal》 被引量: 0发表: 2014年 Molecular characterization of BRCA1 and BRCA2 ...
Inherited mutations in the BRCA1 gene can significantly increase a person's risk of breast and ovarian cancer—but not every mutation in the gene is harmful. To better equip patients and their doctors to understand and manage ...
Breast cancer type 1 susceptibility gene (BRCA1) is a tumor suppressor gene. 乳腺癌易感基因1(BRCA1)是一种抑癌基因表达产物,参与许多重要的细胞生命过程如细胞周期调控、中心体复制、DNA损伤修复等。 2. Objective\ To investigate the expression ofBRCA1and BRCA2 in cyclomastopathy, breast precancerous...
"Not enough men are getting genetic testing to see if they carry a BRCA1 or BRCA2 gene variant that increases their cancer risk," said lead author Heather Cheng, MD, Ph.D., the director of the Fred Hutch Prostate Cancer Genetics Clinic. "And the men who know they are carriers get tes...
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins. About half of the familial breast cancer cases are found to bear mutations in the breast cancer susceptibility gene 1 (BRCA1). The majority of BRCA1 mutati... I Irminger-Finger,BD Siegel,WC ...
The identification and cloning of the familial breast cancer susceptibility gene, BRCA2, has excited much interest in its biological functions. Here, evidence is reviewed that the protein encoded by BRCA2 has an essential role in DNA repair through its association with mRad51, a mammalian homologue...
Breast Cancer susceptibility gene 1 (BRCA1) & Breast Cancer Breast cancer is one of the most common malignancies affecting women worldwide. About 5-10% of all cases are estimated to be familial. Mutations in the BRCA1 (Breast Cancer susceptibility gene 1) gene account for about 15-20% of...