Breast Cancer Susceptibility Gene1 (BRCA1) is a tumor suppressor gene for breast and ovarian cancers. The gene locates at chromosome 17q21 and encodes for 1863 amino acids protein. It is believed that BRCA1 protein is involved in many functions such as DNA repair, centrosome replication, cell...
Breast cancer type 1 susceptibility gene (BRCA1) is a tumor suppressor gene. 乳腺癌易感基因1(BRCA1)是一种抑癌基因表达产物,参与许多重要的细胞生命过程如细胞周期调控、中心体复制、DNA损伤修复等。 2. Objective\ To investigate the expression of BRCA1 and BRCA2 in cyclomastopathy, breast precance...
In 1990, a breast cancer susceptibility gene, designated BRCA1, was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset br...
您现在的位置:生物医药大词典 >> 通用词典 >> 词汇解释: BRCA1,breast cancer susceptibility gene 1 BRCA1,breast cancer susceptibility gene 1分享到: 乳腺癌敏感性基因1分类: 医学 | 查看相关文献(pubmed) | 免费全文文献 详细解释:以下为句子列表:分享到: ...
To date, BRCA1 ortho... S Lafarge,Montané M.‐H - 《Nucleic Acids Research》 被引量: 135发表: 2003年 The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer p pMutations within the BRCA1 tumor suppressor gene occur frequently in familial ...
The identification and cloning of the familial breast cancer susceptibility gene, BRCA2, has excited much interest in its biological functions. Here, evidence is reviewed that the protein encoded by BRCA2 has an essential role in DNA repair through its association with mRad51, a mammalian homologue...
The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent ... Mutations in breast cancer tumor susceptibility genes, and predispose women to early onset breast cancer and other malignancies. The Brca ...
Methylation of Breast Cancer Susceptibility Gene 1 (BRCA1) Predicts Recurrence in Patients With Curatively Resected Stage I Non-small Cell Lung CancerHarada, HiroakiMiyamoto, KazuakiYamashita, YoshinoriNakano, KikuoTaniyama, KiyomiMiyata, Yoshihiro
Twenty-seven patients carried a VUS in a high-penetrance cancer susceptibility gene, and three of those patients also had a deleterious or likely del- eterious variant. Nine patients were found to have a single VUS in BRCA1 or BRCA2, 3 patients had a VUS in TP53, and 12 patients had...
Genetic predisposition is responsible for 5%–10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) ...