1996. Males at-risk for the BRCA1-gene, the psychological impact. Psycho-Oncology 5: 251-257.Dudok deWit AC, Tibben A, Frets PG, Meijers-Hejboer EJ, Devilee P, Niermeijer MF (1996) Males at-risk for the BRCA1-gene, the psychological impact. Psycho-Oncol 5: 251-257...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
"These data will help to optimize medical care in male BRCA1 and BRCA2 PV carriers," Dr. Ottini said. "In particular, screening and surveillance programs in men with BRCA1 and BRCA2 PVs should be tailored in light of these gene-specific cancer phenotype differences." "Overall," she conclu...
"Not enough men are getting genetic testing to see if they carry a BRCA1 or BRCA2 gene variant that increases their cancer risk," said lead author Heather Cheng, MD, Ph.D., the director of the Fred Hutch Prostate Cancer Genetics Clinic. "And the men who know they are carriers get tes...
Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer Article Open access 06 November 2023 Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA...
Prevalence of BRCA1 and BRCA2 Mutations in Male Breast Cancer Patients in Canada Men who inherit a mutation in the BRCA2 gene carry a 6% risk of developing breast cancer by the age of 70. The proportion of male breast cancers attributab... N Wolpert,E Warner,MF Seminsky,... - 《Clin...
29、nal of cancer,2001,91(1):83-88.23 yang d,khan s,sun y,et al.association of brca1 and brca2 mutations with survival,chemotherapy sensitivity,and gene mutator phenotype in patients with ovarian cancerj.jama,2011,67(14):1557-1565.24 lim j s j,tan d s p.understanding resistance mechani...
Women carriers of mutations in the tumor suppressor gene, BRCA1, have an up to 80% risk of developing breast cancer, as well as a 40% risk of ovarian cancer. Men who develop breast cancer are frequently BRCA1 mutation carriers. Moreover,... I Fernandezgarcia,P Ameri,MH Barcelloshoff,....
BRCA1 Also found in:Thesaurus,Medical,Acronyms,Encyclopedia,Wikipedia. Related to BRCA1:BRCA2 n. A gene that is associated with the development of familial breast cancer when inherited in a defective state. [br(east) ca(ncer) 1.] American Heritage® Dictionary of the English Language, Fifth...
A total of 30 Japanese male patients with advanced or metastatic breast cancer in whom two genes (BRCA1, BRCA2) belonging to the homologues recombination gene family with germline pathogenic variants (gPVs) were detected were recommended for treatment with a PARP inhibitor (i.e., olaparib) or...