F. Niermeijer 1996 Males At-Risk for the BRCA1-Gene: the Psychological Impact. Psycho- oncology 5: 251-257.DudokdeWit AC, Tibben A, Frets PG, Meijers-Heijboer EJ, Niermeijer MF (1996): Males at-risk for the BRCA1-gene, the psychological impact. Psycho-Oncology 5:251-257....
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
"These data will help to optimize medical care in male BRCA1 and BRCA2 PV carriers," Dr. Ottini said. "In particular, screening and surveillance programs in men with BRCA1 and BRCA2 PVs should be tailored in light of these gene-specific cancer phenotype differences." "Overall," she conclu...
Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer Article Open access 06 November 2023 Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA...
Prevalence of BRCA1 and BRCA2 Mutations in Male Breast Cancer Patients in Canada Men who inherit a mutation in the BRCA2 gene carry a 6% risk of developing breast cancer by the age of 70. The proportion of male breast cancers attributab... N Wolpert,E Warner,MF Seminsky,... - 《Clin...
"Not enough men are getting genetic testing to see if they carry a BRCA1 or BRCA2 gene variant that increases their cancer risk," said lead author Heather Cheng, MD, Ph.D., the director of the Fred Hutch Prostate Cancer Genetics Clinic. "And the men who know they are carriers get tes...
BRCA1 Also found in:Thesaurus,Medical,Acronyms,Encyclopedia,Wikipedia. Related to BRCA1:BRCA2 n. A gene that is associated with the development of familial breast cancer when inherited in a defective state. [br(east) ca(ncer) 1.] American Heritage® Dictionary of the English Language, Fifth...
29、nal of cancer,2001,91(1):83-88.23 yang d,khan s,sun y,et al.association of brca1 and brca2 mutations with survival,chemotherapy sensitivity,and gene mutator phenotype in patients with ovarian cancerj.jama,2011,67(14):1557-1565.24 lim j s j,tan d s p.understanding resistance mechani...
prostate cancer, pancreatic cancer, and breast cancer in males. There has also been a rapid expansion of US Food and Drug Administration–approved targeted cancer therapies, including poly ADP ribose polymerase (PARP) inhibitors, for breast, pancreatic, and prostate cancers associated withBRCA1/2PVs...
Since the first BRCA1 mutations in early-onset breast and ovarian cancer families were reported, several attempts to establish genotype–phenotype correlations for this gene have been reported. Moreover, in vitro data have suggested dominant-negative effects of putative mutant BRCA1 proteins over ...