F. Niermeijer 1996 Males At-Risk for the BRCA1-Gene: the Psychological Impact. Psycho- oncology 5: 251-257.DudokdeWit AC, Tibben A, Frets PG, Meijers-Heijboer EJ, Niermeijer MF (1996): Males at-risk for the BRCA1-gene, the psychological impact. Psycho-Oncology 5:251-257....
"These data will help to optimize medical care in male BRCA1 and BRCA2 PV carriers," Dr. Ottini said. "In particular, screening and surveillance programs in men with BRCA1 and BRCA2 PVs should be tailored in light of these gene-specific cancer phenotype differences." "Overall," she conclu...
"Not enough men are getting genetic testing to see if they carry a BRCA1 or BRCA2 gene variant that increases their cancer risk," said lead author Heather Cheng, MD, Ph.D., the director of the Fred Hutch Prostate Cancer Genetics Clinic. "And the men who know they are carriers get tes...
Google Share on Facebook BRCA1 Also found in:Thesaurus,Medical,Acronyms,Encyclopedia,Wikipedia. Related to BRCA1:BRCA2 n. A gene that is associated with the development of familial breast cancer when inherited in a defective state. [br(east) ca(ncer) 1.] ...
Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer Article Open access 06 November 2023 Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA...
18、-jarai z,leongamornlert d,saunders e,et al.brca2 is a moderate penetrance gene contributing to young-onset prostate cancer:implications for genetic testing in prostate cancer patientsj.british journal of cancer,2011,105(8):1230-1234.6 agalliu i,gern r,leanza s,et al.associations of hi...
ImportanceHalf of all carriers of inherited cancer-predisposing variants inBRCA1andBRCA2are male, but the implications for their health are underrecognized compared to female individuals. Germline variants inBRCA1andBRCA2(also known as pathogenic or likely pathogenic variants, referred to here asBRCA1...
Since the first BRCA1 mutations in early-onset breast and ovarian cancer families were reported, several attempts to establish genotype–phenotype correlations for this gene have been reported. Moreover, in vitro data have suggested dominant-negative effects of putative mutant BRCA1 proteins over ...
BRCA1 Expression in Canine Mammary Dysplasias and Tumours: Relationship with Prognostic Variables BRCA1 is a nuclear phosphoprotein that participates in the regulation of the cell cycle. The role of the BRCA1 gene in canine mammary tissue and mammary tu... A Nieto,M.D. Pérez-Alenza,ND Castil...
variation by the location of PVs within theBRCA2gene. By contrast, there was no significant variation in the reported overallBRCA1RR estimates by the ethnic ancestry of the study participants. The studies in Ashkenazi Jewish men reported exclusively on the two Ashkenazi founder PVs c.68_69delAG...