Santarosa M et al: BRCA1 and BRCA2 genes: role in hereditary breast and ovarian cancer in Italy. Int J Cancer 1999; 83: 5 ± 9.Santarosa M, Dolcetti R, Magri MD, et al. BRCA1 and BRCA2 gene: role in hereditary breast and ovarian cancer in Italy. Int J Cancer 1999;83:...
Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing. Mol Med Today. 1997; 3 :168–174. [ PubMed ]Gayther SA, Ponder BA. 1997. Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing. Mol Med Today 3:168 -174....
Risk can be influenced by allelic heterogeneity, modifier genes, and environmental and hormonal cofactors. Abstract The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast ...
Large genomic rearrangements of the BRCA1 and BRCA2 genes: review of the literature and report of a novel BRCA1 mutation. Breast Cancer Res Treat 2011; 125(2): 325-49.Sluiter,M.D. and van Rensburg,E.J. (2011) Large genomic rearrangements of the BRCA1 and BRCA2 genes: review of the...
raised controversial ethical and legal issues relating to access and research, and its enforcement caused growing discontent. In the USA, the validity of the patents on the isolated BRCA1 and BRCA2 genes was challenged in court. After a four-year legal battle, the US Supreme Court invalidated ...
摘要: BRCA1 and BRCA2 are cancer-predisposition genes, germ line mutations which are associated with a high risk of developing breast cancer, ovarian cancer, and other cancers. Much information has been...DOI: 10.1007/978-3-642-16483-5_718 ...
BRCA1 and BRCA2: different roles in a common pathway of genome protection. The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two ... R Roy,J Chun,SN Powell - 《Nature Reviews Cancer》 ...
Mutations in these two genes attribute to approximately 5% of the total of breast cancers. We wanted to determine the uptake of presymptomatic. BRCA1/2 DNA testing (PST) in families in which a mutation was known. In addition we analysed the chosen preventive interventions and the incidence of...
BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with many cases of early-onset breast cancer. However, in an outbred population, the prevalence of BRCA1 and BRCA2 mutations in patients with breast cancer who were...
We report an extremely rare case of familial breast cancer with deleterious germline mutations in both BRCA1 and BRCA2 genes, of which, to date, no such case has been reported among Japanese breast/ovarian cancer patients. Genetic testing of the family members indicated that the same double het...