携带DNA损伤反应(DNA damage response,DDR)基因(包括BRCA1/2、PALB2、ATM、CHEK2等)突变的转移性去势抵抗的前列腺癌患者,可以显著地获益于PARP抑制剂的治疗,文献报道总缓解率(overall response rate)最高可达88%。 3 BRCA1/2基因突变与相关肿瘤预后 肿瘤预后判断需要考虑多...
The proteins encoded by the two major breast cancer susceptibility genes,BRCA1andBRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair. BRCA1 is a pleiotropic DDR protein that functions in...
BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) encode for proteins that are well-known mediators of DNA damage response and particularly of double-strand breaks (DSBs) through Homologous Recombination (HR) [1,2]. Since the discovery ofBRCA1andBRCA2genes in the early 1990s,...
Color bar coding the BRCA1 gene on combed DNA: a useful strategy for detecting large gene rearrangements. Genes Chromosom. Cancer 31, 75–84 (2001). CAS PubMed Google Scholar Gad, S. et al. Bar code screening on combed DNA for large rearrangements of the BRCA1 and BRCA2 genes in ...
Background The homologous recombination (HR) repair pathway for DNA damage, particularly the BRCA1 and BRCA2 genes, has become a target for cancer therapy, with poly ADP-ribose polymerase (PARP) inhibitors showing significant outcomes in treating germline BRCA1/2 (gBRCA1/2) mutated breast ...
Oncology and CarcinogenesisTumors lacking theBRCA1andBRCA2(BRCA) hereditary breast cancer genes display heightened sensitivity to anti-cancer treatments, such as inhibitors of poly (ADP-ribose) polymerase 1 (PARP1). However, when resistance develops, treatments are lacking. Using CRISPR technology, we...
The role of the familial breast cancer susceptibility genes, BRCA1 and BRCA2, in the homologous recombination (HR) pathway for DNA double-strand break (DSB... Ding Shian-ling,Yu Jyh-Cherng,Chen Shou-Tung,... - 《Carcinogenesis》 被引量: 109发表: 2009年 ...
BRCA1 and BRCA2, the two major genes regulating genome protection at various stages of the DNA damage response and DNA repair, are well-known breast and ovarian cancer-susceptibility genes [1,2,3,4]. While the retrospective studies have suggested that the cancer risk might vary between BRCA1...
Among these 39 genes, the tumor suppressor gene, BRCA1, was found to be more sensitive to DNA damage in the AnSCs compared to that in the deer somatic cells, and BRCA1 deletion in the AnSCs via CRISPR/Cas9 resulted in significantly higher levels of DNA damage. Lack of BRCA1 promoted ...
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode produ... JJ Chen,DP Silver,SB Cantor,... - 《Cancer Research》 ...