Radiotherapy is the most effective modality of brain tumour control and is described with respect to the new refinements of interstitial and stereotactic radiosurgery. Attention is given to developments in chemotherapy. Improvement in outcome for patients will be achieved by optimization of focal tumour ...
5. If you can't surgically remove the tumor, will I need other treatments, such as chemotherapy or radiotherapy? 6. What are the possible side effects of these therapies? 7. Who might my treatment team include, and for how long will I continue to see them? 8. Are there alternative tre...
local radiotherapy to the tumor site, and tumor treating fields should be considered as standard treatments.43,44,45,46All GBM will finally progress or relapse to recurrent GBM (rGBM), while without standard treatment. In addition, bevacizumab, known as an anti-vascular...
is the most common malignant brain tumor and has a 5-year survival rate of 5.6%125. Despite multimodal treatment, including surgical resection, radiation, and standard therapy with temozolomide (TMZ), the prognosis is universally poor due to therapy resistance and recurrence126,127,128. Therefore,...
The forthcoming results of ICI-based therapeutic combination(s) in patients with brain disease may soon lead to significant changes in their comprehensive management, thus revisiting the role of surgery and radiotherapy in CNS metastases. Nevertheless, the efficacy of ICI therapy on brain metastases fr...
“It is scandalous to think that there have been no improvements to treatment options for this type of tumour in two decades and the standard of care for GBM patients – surgical resection followed by radiotherapy and chemotherapy – remains unchanged. ...
tumour. This is accomplished by employing special procedures that focus the radiation. For instance, a device called agamma knife, which emits a highly controllable beam of radiation, may be used. Even when radiation is localized, however, radiotherapy can causeside effectssuch as vomiting, ...
and respond well to standard radiotherapy and chemotherapy treatments, astrocytomas are highly invasive and difficult to treat. For this reason they are also associated with a poor prognosis: sufferers usually only survive for a few years. In Austria around 400 people develop an astrocytoma every ...
The NK cell numbers in the brain tumor microenvironment are often depleted, especially after chemo-radiotherapy because of inflammatory mediators like transforming growth factor-β (TGF-β), COX, and prostaglandin E235,36. In a case series of four patients with DIPG, lymphocyte profiling revealed de...
prognosis determination, and treatment response assessment. It also facilitates surgical and nonsurgical treatment planning21, accelerates drug discovery22, and facilitates recurrence monitoring. AI tools can be incorporated into clinical trials, aiming to improve patient outcomes and may provide the path to...