Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults. Despite significant advances in treatment and intensive research, the prognosis for patients with GBM remains poor. Therapeutic challenges for GBM include its invasive nature, the proximity of the tumor to vital brain ...
As with most other tumors, early detection and remediation correlates with a positive prognosis. Currently an invasive biopsy is the preferred method to confirm the diagnosis of cancer as it can provide information about histological type, classification, grade, potential aggressiveness and other ...
When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targetingbreast cancer cellsin the brain aren't effective, because the...
Brain metastases (BM) occur frequently in many cancers, particularly non-small cell lung cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with poor prognosis and has an adverse impact on survival and quality of life. Commonly used therapies for BM such as surger...
Fig. 1: Mechanisms of NK cell deactivation in the brain tumor microenvironment. Mechanisms of NK cell deactivation by cancer cells include the expression of MHC-I, PD-1, CD155, and CD73 expression on cancer cells that can inhibit NK cells. Cytokine and chemokine release, such as IL-6, IL...
To the Editor, Brain metastases are frequent in HER2 -positive breast cancer and are associated with poor prognosis. Severe neurological symptoms such as neurocognitive decline, aphasia, paresis, seizures and impaired quality of life are common. The standard therapy options for brain metastases compris...
However, at this time molecular genetic analysis of gliomas does not provide better prognosis than histopathological staging. Recently, experimental treatments of gliomas in rodents, using gene therapy, have been reported. Results of these studies have been promising, and these techniques may represent ...
Find all the latest on cancer therapy at Medical Xpress. Your go-to source for news, research, and medical breakthroughs.
Malignant gliomas (anaplastic astrocytoma and Glioblastoma multiforme), the most malignant brain tumors, have a poor prognosis because of their widely invasive nature, which makes a complete resection almost impossible. The current standard first-line therapy with surgery, radiotherapy, and subsequent ...
A high level of Carcinoembryonic antigen (CEA) is known to be associated with poor cancer prognosis [61]. For this reason CEA has been targeted for the treatment of lung [62], breast [63], pancreatic and gastric cancers [64,65], and it is considered as one of the most promising target...