The trend of using nanoparticles for the overall upliftment of brain cancers has been explored in detail. Finally, the chapter is concluded by highlighting the potential usage of nanomedicine in the area of brain cancer research, its future perspectives, and challenges....
When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targetingbreast cancer cellsin the brain aren't effective, because the...
Brain metastases are a common complication of cancer and continue to be associated with a poor prognosis. Management of brain metastases typically requires a multidisciplinary approach which may include whole-brain radiation therapy, stereotactic radiosurgery, surgery, and systemic therapy. Historically, ...
To the Editor, Brain metastases are frequent in HER2 -positive breast cancer and are associated with poor prognosis. Severe neurological symptoms such as neurocognitive decline, aphasia, paresis, seizures and impaired quality of life are common. The standard therapy options for brain metastases compris...
Advancements in human genomics over the last two decades have shown that cancer is mediated by somatic aberration in the host genome. This discovery has incited enthusiasm among cancer researchers; many now use therapeutic approaches in genetic manipulat
HER2-positive breast cancer brain metastases (BCBM) are characterized by multiple small lesions. They are often accompanied by leptomeningeal metastases, and those with meningeal metastases tend to have a poor prognosis [9]. Radiotherapy is the primary strategy for local treatment of patients with ...
Israeli researchers at the Hebrew University Hadassah Medical School made a ground breaking discovery of a cancer-driving protein.
Fig. 1: Mechanisms of NK cell deactivation in the brain tumor microenvironment. Mechanisms of NK cell deactivation by cancer cells include the expression of MHC-I, PD-1, CD155, and CD73 expression on cancer cells that can inhibit NK cells. Cytokine and chemokine release, such as IL-6, IL...
- 《Clinical Cancer Research An Official Journal of the American Association for Cancer Research》 被引量: 346发表: 2010年 Survival of patients with non-small-cell lung cancer after a diagnosis of brain metastases Background;The prognosis of patients with brain metastases from non-small-cell lung...
Cyclic guanosine monophosphate-adenosine monophosphate adenosine synthetase (cGAS) is a DNA sensor that detects and binds to cytosolic DNA to generate cyclic GMP-AMP (cGAMP). As a second messenger, cGAMP mainly activates the adapter protein STING, which