IDing IDH1 via biomarker NMR has the potential to predict the prognosis and response to treatment of patients with low-grade infiltrating brain cancer, gliomas, that have mutations in the isocitrate dehydrogenase 1 IDH1 gene, according to ex vivo and in vivo imaging studies. Adam Elkhaled, ...
McCain,diagnosed with Glioblastoma, an aggressive form of brain cancer late last month, has already successfully undergone his first round of radiation and chemotherapy and spent most of his recess at home with family.He returned back to Washington for work in the Senate late last week. He left...
The incidences of brain metastases from breast cancer have recently increased due to prolonged survival of the patients and the development of imaging techniques. However, there is little information regarding the optimal treatments and the prognosis for these patients. Identification of subgroups of ...
Objectives Limited data is available on head and neck cancer (HNC) patients presenting with brain metastases (BM) at initial diagnosis. We sought to evaluate the incidence, management, and treatment outcomes of these patients using the National Cancer Database (NCDB). Methods We identified 465,925...
dataset to build predictive models of prognosis and drug response for TCGA. We also use TCGA RNA-seq read counts to build equivalent predictive models for comparison. We show that in four cancer types, adrenocortical carcinoma, cervical squamous cell carcinoma, brain lower grade glioma, and ...
e11117 Background: Prognosis of young women's breast cancer is influenced by reproductive history with worse prognosis when diagnosis is within five years postpartum. We propose that breast involution accounts for the poor prognosis of p... V Borges,T Lyons,J O'Brien,... - 《Journal of Cli...
Admission for seizures was independently associated with lower ICU mortality [odds ratio (OR) 0.06], whereas the need for mechanical ventilation (OR 6.85), cancer progression (OR 7.84), respiratory rate (OR 1.11) and Glasgow coma scale (OR 0.85) were associated with higher ICU mortality. Among...
deep learning may be applied in cancer diagnosis, prognosis and treatment management. We also assess the current limitations and challenges for the application of deep learning in precision oncology, including the lack of phenotypically rich data and the need for more explainable deep learning models....
DICER—responsible for the processing of microRNA precursors—was previously linked to poor clinical outcomes in cancer patients. Here, the authors uncover an epigenetic mechanism by which hypoxia suppresses DICER expression and deregulates the miR-200-Zeb1 circuit in breast cancer to promote the ...