MODL-25. Radiation and focused ultrasound–mediated blood–brain barrier opening for DMG: safety and feasibility of combinatorial therapydoi:10.1093/neuonc/noac079.648Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic therapeutic strategies have been unsuccessful to date ...
Focused Ultrasound for Neuro-oncological Applications Brain tumors, particularly malignant lesions such as glioma, represent a daunting challenge for both physicians and patients. These tumors are characterized by an awful prognosis and a treatment able to control these diseases constitutes a major unmet ...
Biomarker detection in brain tumors can be crucial in providing information on the diagnosis, prognosis, and development of individualized treatment for patients harboring targetable molecular changes, which has led to the integration of molecular marker detection in clinical practice [32]. Traditional ...
Glioblastoma (GB) is one of the most aggressive and difficult-to-treat brain tumors, with a poor prognosis and limited treatment options. In recent years, sonodynamic therapy (SDT) and magnetic resonance focused ultrasound (MRgFUS) have emerged as promising approaches for the treatment of GB. S...
RADT-17. FOCUSED ULTRASOUND MEDIATED BLOOD–BRAIN BARRIER OPENING IS SAFE AND FEASIBLE CONCURRENT WITH AND ADJUVANT TO A CLINICAL RADIATION SCHEME FOR BRAINSTEM DMGDiffuse midline gliomas (DMG) are pediatric tumors with dismal prognosis. When these tumors emerge in the brainstem, there exists no ...
BLOOD-brain barrierBRAIN stemCENTRAL nervous systemGLIOMASMAGNETIC resonance imagingRADIOTHERAPYBackground: Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A centra...
Pancreatic ductal adenocarcinoma (PDAC) diagnosis accompanies a somber prognosis for the patient, with dismal survival odds: 5% at 5 years. Despite extensive research, PDAC is expected to become the second leading cause of mortality by cancer by 2030. Ultrasound (US) has been used successfully in...