Increasing evidence has shown how neurodevelopmental and neuronal-like mechanisms are hijacked leading to the discovery of multicellular brain tumor networks. Here, we review how gap junction-coupled tumor-tumor-astrocyte networks, as well as synaptic and paracrine neuron-tumor networks drive glioma ...
Glioma is a frequent primary brain tumor originating from glial cells. Based on the WHO CNS5 in 2021, gliomas are classified into adult-type diffuse gliomas, pediatric-type diffuse low-grade and high-grade gliomas (LGG and HGG), as well as circumscribed astrocytic gliomas.11The localized glioma...
due to both the tumor itself and its treatment. In this study, we explored the role of structural whole-brain and nodal network metrics and their association with cognitive functioning. Fifty WHO grade 2–3 adult glioma survivors (> 1-year post-therapy) and 50 matched healthy controls under...
a mathematical model of glioma growth and diffusion was developed based on the analysis of serial ct scans of a patient with recurrent anaplastic astrocytoma. the developed model was an isotropic diffusion model that allowed tumor cells to diffuse equally in all directions with the same speed for ...
β1-INTEGRINS MEDIATE DIFFUSE BRAIN INVASION OF GLIOMA CELLS IN VIVO W Paulus,I Baur,SA Reeves - 《Journal of Neuropathology & Experimental Neurology》 被引量: 0发表: 1996年 Diffuse brain invasion of glioma cells requires beta 1 integrins. Diffuse invasion of brain tissue by single tumor cells...
PallabiSharma, ...RajashreeNayak, inNeural Networks, 2024 5.7Brain cancer A brain tumor is a mass-like structure of alive and dead cells that start to grow uncontrollably inside the brain. It is considered one of the deadliest forms of cancer across the globe that affects individuals of all ...
由复旦大学附属华山医院神经外科吴劲松教授团队历时12年,在今年1月于《European Journal of Cancer(欧洲癌症杂志)》上发表文章《Effect of high-field iMRI guided resection in cerebral glioma surgery: A randomized clinical trial(高场强术中磁共振在脑胶质瘤手术中效应:随机对照验证试验)》,该临床试验是第一个精心...
In 1963, mGBM were classified into multifocal and multicentric GBM depending on the distance between the tumor lesions and on the presence or absence of a connection between them [8]. While multifocal GBM have at least one visible connection on T2-weighted imaging, by definition no such ...
burgeoning insights into the tumor microenvironment, particularly the immunosuppressive milieu engendered by tumor–brain interplay, posit immunotherapy as a promising avenue for ameliorating brain metastases. In this review, we meticulously delineate the research advancements concerning the microenvironment of br...
networks that extend to the contralateral hemisphere, accompanied by global attenuation of the rsfmri signal. preliminary histology suggests that some of these alterations in brain connectivity may be attributable to tumor-related remodeling of the neurovasculature. moreover, this work recapitulates ...