Brain tumorGliomaDormancyEndogenous inhibitionAngiogenesisMetastasisThe growth inhibition of remote metastases by a primary tumor is known as endogenous growth inhibition leading to tumor dormancy. Such a phenotype has not be...
A glioma is a primary brain tumor, meaning it grows from the brain tissue itself. Glial cells support neurons with energy and maintain the blood-brain barrier. Each type of glial cell has a different role: Astrocyte- transports nutrients and holds neurons in place Oligodendrocyte- provides insula...
Laboratory studies have demonstrated the activity of irinotecan in a broad panel of pediatric and adult central nervous system tumor xenografts in athymic nude mice. These studies led to a Phase II trial that confirmed the activity of this agent in the treatment of recurrent malignant glioma. ...
Reprogramming the fate of human glio-ma cells to impede brain tumor development. Su Z,Zang T,Liu ML,et al. Cell DeathDis . 2014Su, Z., Zang, T., Liu, M.L., Wang, L.L., Niu, W., and Zhang, C.-L. (2014). Reprogramming the fate of human glioma cells to impede brain ...
A2B5+ oligodendrocytes and NeuN+ cells in vitro (Supplementary FigureS1B). To examine if the Cd133+/Nestin+ hGSCs can recapitulate the complexity and heterogeneity of the original tumor they were transplanted into the brain of immunocompromised mice under stereotactic guidance. Four weeks after tra...
Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst. 2011;103(15):1162-1178. http://dx.doi... HA Fine - 《Jnci Journal of the National Cancer Institu...
The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (16 selected papers from 21 submissions); brain tumor image segmentation (69 selected papers from 75 submissions); and computational precision medicine: radiology-pathology...
This book constitutes the thoroughly refereed post-workshop proceedings of the International Workshop on Brain Lesion (BrainLes), Brain Tumor Segmentation (BRATS) and Ischemic Stroke Lesion Segmentation (ISLES), held in Munich, Germany, on October 5, 2015, in conjunction with the International Confe...
Zagzag D, Brem S, Robert F: Neovascularization and tumor growth in the rabbit brain. Am J Pathol 131: 361–372, 1988 PubMed Google Scholar Fan T-PD, Brem S: Angiosuppression.In: The Search for New Anticancer Drugs, Cancer Biology Series. M.J. Waring and B. Ponder, (eds), Vol....
Presence of IL-33 in inflammatory GBM One potential reason that many promising in vitro studies fail at the preclinical/clinical level with respect to brain tumor therapies is that the tumor microenvironment, and in particular the immune component, plays a direct role in contributing to therapeutic...