The growth inhibition of remote metastases by a primary tumor is known as endogenous growth inhibition leading to tumor dormancy. Such a phenotype has not been described in primary malignant gliomas. However, although glioma cells have frequently spread to other parts of the brain at the time of...
Glioma is a tumor occurring in the brain and one of the most devastating cancers, affecting children and young adults and having a very high morbidity with poor prognosis. The propensity of glioma cells to invade normal brain structures and to resist current treatments makes new therapeutic strateg...
Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial...
tumor cells in the injected site when we used core-derived 1051 sphere cells, whereas most of the edge-derived 1051 cells infiltrated into the corpus callosum—one of the major brain regions of GBM cell invasion30(Fig.2a). Based on the GSEA data in Fig.1, we then performed IHC with ...
Targeting oncogenic pathways that are essential to the survival and growth of brain tumor stem cells represents a promising area for developing therapeutics. However, due to the multiple oncogenic pathways involved in glioma, it is necessary to determine which pathways are the essential targets for ...
Presence of IL-33 in inflammatory GBM One potential reason that many promising in vitro studies fail at the preclinical/clinical level with respect to brain tumor therapies is that the tumor microenvironment, and in particular the immune component, plays a direct role in contributing to therapeutic...
CMES本期精选文章“GliomaCNN: An Effective Lightweight CNN Model in Assessment of Classifying Brain Tumor from Magnetic Resonance Images Using Explainable AI”(GliomaCNN:使用可解释AI从磁共振图像中评估脑肿瘤分类的有效轻量级CNN模型)。 文章背景
3.2.2. Promotion of Tumor Invasion by GAMs 3.2.3. Roles of GAMs for Changing Microenvironments 3.3. Glioma Cell 3.3.1. Tumor Cell Membrane Tube Network Tumor microtube is very novel target. Beside the Cx43, which was mentioned by this review, KCa3.1, which was just reported in a Nature...
Brain Tumor, DIPG、DIPG、DIPG - diffuse intrinsic pontine glioma + [13] 简介 A rare, aggressive brain tumor that forms in the GLIAL CELLS in the PONS. 关联 40 项与 弥漫内生性脑桥神经胶质瘤 相关的药物 Dianhydrodulcitol 去水卫矛醇 靶点 DNA 作用机制 DNA抑制剂 [+3] 在研机构 Kintara The...
Because some residual glioma cells always remain in the tumor resection margin, there are now compelling arguments to suggest that some aspects of the brain tissue response to SBI can also participate to glioma recurrence at the resection margin. Brain tissue response to SBI recruits angiogenesis ...