Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because of their capability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. According to the CSC ...
Despite continued advances in surgical and medical therapies, the outcomes for patients diagnosed with glioblastoma multiforme remain dismal. Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because ...
considered that in contrast to diffuse low-grade tumors, with glioblastoma there is less time for plasticity-based “rewiring” of the brain. Thus, supramarginal strategies will be limited where speech, memory and motor functions are not inside the immediate infiltration zone starting at the edge o...
This review summarizes important signaling pathways employed by both normal and cancer stem cells and highlights promising molecular-targeted therapies interfering with those signaling pathways in malignant gliomas. 展开 关键词: Animals Humans Glioma Brain Neoplasms Signal Transduction Neoplastic Stem Cells ...
Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers.doi:10.1038/nature05236Bao, ShidengWu, QiulianMcLendon, Roger E.Hao, YuelingShi, Qing
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Cancer stem cells (CSC) are predicted to be critical drivers of tumor progression due to their self-renewal capacity and limitless proliferative potential. An emerging area of research suggests that CSC may also support tumor progression by promoting tumor angiogenesis. To investigate how CSC contribut...
lncRNA, INHEG, which interacts with NOP58 and promotes NOP58 sumoylation and downstream rRNA methylation. This process supports GSC self-renewal and tumorigenesis, offering a further understanding of rRNA methylation in cancer stem cells and providing potential therapeutic targets for lethal cancer. ...
Glioblastoma (GBM) is the most frequent and malignant brain tumor with an overall survival of only 14.6months. Although these tumors are treated with surgery, radiation and chemotherapy, recurrence is inevitable. A critical population of tumor cells in terms of therapy, the so-called cancer stem ...
Glioblastoma multiforme (GBM) is the most frequently encountered brain cancer. Although the existence of cancer stem cells in GBM has been previously established, there is little evidence to explain the difference between cancer stem cells and radio-resistant cells in GBM. In an effort to increase...