In brain endothelial cells NF-κB protects the blood-brain barrier. Loss of the NF-κB activating protein NEMO in brain endothelial cells leads to endothelial cell death, increased permeability, and epilepsy inmice as well as in humans with the hereditary disease incontinentia pigmenti. Therefore,...
Imaging the role of blood–brain barrier disruption in normal cognitive ageing. GeroScience 42, 1751–1764 (2020). Article PubMed PubMed Central Google Scholar Li, Y. et al. The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study. Clin...
In subject area: Physics and Astronomy The blood-brain barrier (BBB) is a physical barrier in the central nervous system (CNS) that regulates the entry of molecules from the bloodstream to the brain, protecting it from harmful substances. It is composed of specialized endothelial cells, astrocyte...
There was also no significant difference between the control value and the GABA-treated animals (P> 0.5). These results have shown that an abrupt increase in blood pressure (ΔP) did not change the blood–brain barrier permeability in both acute hypertension and seizures....
Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements Introduction The blood-brain barrier (BBB) separates the central nervous system (CNS) from the peripheral tissues. In order to maintain homeostasis in the CNS, the BBB controls material, nut...
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and bioph
The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain barrier (BBB), composed of brain microvascular endothelial cells and assoc
In this narrative review, a theoretical framework on the crosstalk between physical exercise and blood-brain barrier (BBB) permeability is presented. We discuss the influence of physical activity on the factors affecting BBB permeability such as systemic inflammation, the brain renin-angiotensin and nor...
Objective Tuberous sclerosis complex (TSC) is a genetic disorder, characterized by tumor formation in the brain and other organs, and severe neurological symptoms, such as epilepsy. Abnormal vascular endothelial growth factor (VEGF) expression may promote angiogenesis in kidney and lung tumors in TSC...
The blood-brain barrier (BBB) is an elaborate structure of utmost importance, as it separates the brain compartment and the peripheral organs, allowing the creation of a unique brain environment for optimal neuronal activity. Endothelial cells of brain microvasculature present special properties that re...