The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γand CB2 pathways. del Rio C,Navarrete C,Collado JA.et al. Science Reports . 2016
Scleroderma is an inflammatory autoimmune disease which begins with inflammation due to tissue injury and advances to progressive accumulation of extracellular matrix resulting in scarring and hardening of the skin. Inflammation is a salutary response to tissue injury caused by varied factors. While ...
We have recently established a mouse model for scleroderma by repeated injections of bleomycin. In this study, we examined whether the suppression of TGF-β leads to the improvement of dermal sclerotic lesion by using this model. We induced dermal sclerosis in C3H mice by subcutaneous injections ...
The NLRP3 inflammasome and IL-1β are essential for scleroderma pathogenesis. Nevertheless, the role of pyroptosis executor gasdermin D(GSDMD), which is a downstream molecule of NLRP3 and is required for IL-1β release in some situations, has not yet bee
Altered Expression of Neuropeptide Receptors in the Bleomycin (Bleo)-Induced Mouse Model of Scleroderma (SSc)The ideal regimen for induction of labor with oxytocin with respect to the magnitude and frequency of dosage changes has not been defined. In spite of few data regarding labor induction ...
Role of Monocyte Chemoattractant Protein-1 and its Receptor,CCR-2, in the Pathogenesis of Bleomycin-Induced Scleroderma Systemic sclerosis is a connective tissue disease characterized by excessive deposition of extracellular matrix in the skin as well as various internal org... T Yamamoto,K Nishioka ...
Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum. 2001;44:2653–64. Article CAS PubMed Google Scholar Cho HY, Kleeberger SR. Noblesse ...
Scleroderma (systemic sclerosis) is a chronic inflammatory disease that progresses with vascular damage, immunological abnormalities, and exten- sive fibrosis. Rituximab, an antibody against the B- lymphocyte-specific CD20 surface marker leads to depletion of B cell counts and functions. This study aims...
Endoglin promotes TGF-beta/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol. 2011;226:3340–8. Article CAS PubMed PubMed Central Google Scholar van den Bosch MH, Blom AB, van Lent PL, van Beuningen HM, Blaney Davidson EN, van der Kraan PM, et al. Canonical Wnt signaling ...
The etiology of idiopathic pulmonary fibrosis (IPF) is not well known, however it is a final response of frequent injuries to endothelial and epithelial cells that cause influx of the inflammatory cells. Bleomycin (BLM), a chemotherapeutic agent that causes lung fibrosis in human patients has been...