T. Yamamoto, "The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis?" Archives of Dermatological Research, vol. 297, no. 8, pp. 333-344, 2006.Yamamoto T: The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis? Arch Dermatol...
Vorstenbosch J, Al-Ajmi H, Winocour S, Trzeciak A, Lessard L, Philip A (2013) CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma. Arthritis Rheum 65:1378–1383Vorstenbosch J, et al. CD109 overexpression ameliorates skin fibrosis in a mouse model...
Altered Expression of Neuropeptide Receptors in the Bleomycin (Bleo)-Induced Mouse Model of Scleroderma (SSc)The ideal regimen for induction of labor with oxytocin with respect to the magnitude and frequency of dosage changes has not been defined. In spite of few data regarding labor induction ...
The NLRP3 inflammasome and IL-1β are essential for scleroderma pathogenesis. Nevertheless, the role of pyroptosis executor gasdermin D(GSDMD), which is a downstream molecule of NLRP3 and is required for IL-1β release in some situations, has not yet bee
commonly used to studyscleroderma. Another advantage of the model is that it is chronic and progressive. However, thischronicitycan also be seen as a disadvantage given the time and cost required to perform an experiment. As with most of the other mouse models described in this article, ...
Adenosine A2a Receptor Blockade Diminishes Wnt/β-Catenin Signaling in a Murine Model of Bleomycin-Induced Dermal Fibrosis.doi:10.1016/j.ajpath.2017.05.005Adenosine A2a receptor (A2aR) stimulation promotes the synthesis of collagens I and III, and we have recently demonstrated that there is ...
Fig. 1: Increased Gal-3 expression in BLM induced PF mice and FMD process in HFL1 cells. PF was induced by intratracheal instillation of BLM in vivo. FMD model was constructed by further stimulation of HFL1 with TGF-β1 in vitro. Western blot results (a) and statistical analysis (b) ...
Scleroderma-like skin changes have been reported. Skin toxicity is a relatively late manifestation usually developing in the second and third week of treatment after 150 to 200 units of bleomycin have been administered and appears to be related to the cumulative dose. Intrapleural administration of ...
关键词: Scleroderma Systemic Pulmonary Fibrosis Polymorphism Genetic DOI: 10.1136/ard-2024-226034 年份: 2025 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Elsevier dx.doi.org 科研支点 相似文献Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and ...
Nog +/LacZ mice are a known model of increased BMP signaling and were partially protected from bleomycin-induced lung fibrosis with reduced Ashcroft score, reduced collagen content and preservation of pulmonary compliance. In bleomycin-induced lung fibrosis, TGFβ and BMP signaling followed an inverse...