The mode of action of bleomycin after intraarterial perfusion in 53 patients with advanced squamous cell carcinoma of the oral cavity is reported on the basis of clinical results and pathologico-anatomic findings. In 29 out of 32 cases not previously treated a clinically complete remission could ...
Mechanism of Action Although the exact mechanism of action of bleomycin is unknown, available evidence indicates that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. Bleomycin is known to cause single, and to a less...
More studies are required to identify whether differences in Blmh are due to reduced expression or an alternative mode of action. Alternatively, one can consider the possibility that pulmonary cells express higher levels of a putative BLM transporter. Although this hypothesis would be consistent with...
Bleomycin (blm) is aglycopeptide antitumor antibiotic that has been employed in anticancer chemotherapy for more than 2 decades. It is active in a variety of human tumors, most notably testicular cancer, lymphomas, and squamous cell carcinoma of the head and neck. Its lack of myelotoxicity led ...
Aerated cells can progress into phases of the cell cycle where they are more sensitive to killing by BLM. Misoinidazole (=Ro-07-0582) was used in combination with BLM, since its mode of action has been shown to be psecific for killing hypoxic cells. It concomitant use with BLM could ...
Researchers in the USA have obtained the first X-ray structure of the well-known anticancer agent bleomycin complexed to its target DNA. The study offers important clues as to the drug's mode of action and may point drug designers in the right direction to devise more targeted analogues for ...
FtsZ Directs a Second Mode of Peptidoglycan Synthesis in Escherichia coli Certain penicillin binding protein mutants of Escherichia coli grow with spirillum-like morphologies when the FtsZ protein is inhibited, suggesting that Ft... A Varma,MAD Pedro,KD Young - 《Journal of Bacteriology》 被引量:...
for 5 min in plus mode (3 s plus and 3 s break) at 75% of its power (130 W). The prepared NXZD-loaded dispersion was kept in amber glass vials at 4ºC until use. The final concentration of NXZD in the prepared dispersion was 10 mg/g. 2.3. Morphology, particle size and ...
The chemical structure and action mode of bleomycin have been extensively studied; in contrast, the molecular mechanisms of the cytotoxic effects of bleomycin, in vivo, remain poorly understood. Recently, the apoptotics signaling pathway induce by bleomycin was the object of study of many groups. ...
In various base adducts of the low-spin BLM-FeIII complex, there was a good correlation between the gz value and the g value splitting (gz - gx), which is related to the axial ligation mode to the iron. The ESR parameters (gx = 2.039, gy = 1.969, gz = 2.008, and AN = 23.8 G...