Bleomycin-induced lung injury. UpToDate 2012. Available at http://www.uptodate.com/contents/bleomycin-induced-lung-injury . Accessed 11 June 2013.Reinert T, Baldotto CSdR, Nunes FAP, et al. Bleomycin- induced lung injury. J Cancer Res 2013; 9 pp. doi:10.1155/2013/480608....
bleomycingerm celllung toxicityovarian cancerBleomycin, an antibiotic agent with antitumour activity, is an important drug in the management of many oncological malignancies such as lymphoma and germ cell tumours. These tumours are potentially curable and mostly affect young people. The potential side ...
Therefore, our aim was to investigate the effects of dexamethasone in an animal model of bleomycin-induced acute lung injury and then to determine if the lack of response could be related to an impairment in repair ability of alveolar epithelial cells after injury. NMRI mice were challenged with...
Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that can recognize a variety of ligands and play an important role in mediat
The present study was designed to determine the protective effects of curcumin against bleomycin (BLM)-induced inflammatory and oxidant lung injury. The data indicate that BLM-mediated lung injury resulted in increases in lung lavage fluid biomarkers such as total protein, angiotensin-converting enzyme...
Preventive and therapeutic effects of physical exercise on bleomycin-induced lung injury and oxidative stressAtividade FísicaAptidão físicaSaúdeExercícioEstresse oxidativoPulmãoBleomicinaRadicais livresPhysical exerciseOxidative stressStudies have shown that regular physical exercise of moderate intensity ...
Moreover, bleomycin is also known to produce lung injury and fibrosis in humans as well as in experimental animals[4]. The Chinese traditional herb Tripterygium wilfordii Hook F and its extracts have been widely used in the treatment of autoimmune diseases, including rheumatoid arthritis and ...
(senescence-associated secretory phenotype; SASP) as a trigger for the secretion of various medi-ators which modify the processes of tissue injury, inflammation, repair and fibrosis. We characterizedthe SASP in a murine model of bleomycin-induced lung injury. Mice were intratracheally administered...
IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury. Braun RK,Ferrick C,Neubauer P,... RK Braun,C ...
Transforming growth factor (TGF)-β1 is a potent mediator known to induce lung fibrosis. However, the role of latent TGF-β1 in lung inflammation and fibrosis is unclear. To investigate the role of circulating latent TGF-β1 in bleomycin-induced lung injury, lung disease was induced in kerat...