INTERSTITIAL lung diseasesADENO-associated virusPHENOTYPIC plasticityWe have previously established a novel mouse model of lung fibrosis based on Adeno-associated virus (AAV)-mediated pulmonary overexpression of TGF尾1. Here, we provide an in-depth characterization of phenotypic and transcriptomic changes ...
Signs of bleomycin toxicity usually are insidious with nonspecific, subacute symptoms characteristic of interstitial lung disease (cough, dyspnea, low-grade fever, tachypnea). Symptoms typically appear 1 to 6 months after completion of therapy and progress toward lung fibrosis. A more acute, rapid ...
It has been hypothesized that Tβ4 may exert a cyto-protective effect during lung injury because lower Tβ4 levels were associated with interstitial lung disease progression. Moreover, Tβ4 treatment prevented profibrotic gene expression in cardiac cells in vitro and in vivo.Materials and method...
(Dlco). As the illness progresses, there is a decline in vital capacity andtotal lung capacity, characteristic ofrestrictive lung disease. In bothinterstitial pneumonitisand hypersensivity lung reactions, patients typically present with a dry hackingcoughand dyspnea; these signs occur only on exertion...
Conclusion: LLDT-8 showed protective effects against bleomycin-induced lung fibrosis, and the results suggested the potential role of LLDT-8 in the treatment of this disease. Introduction Idiopathic pulmonary fibrosis is a chronic, progressive form of interstitial lung disease, associated with an ...
Interstitial lung disease IPF: Idiopathic pulmonary fibrosis KEGG: Kyoto Encyclopedia of Genes and Genomes LC–MS: Liquid chromatography–mass spectrometry PCR: Polymerase chain reaction PEF: Peak expiratory flow PET: Positron Emission Computed Tomography PF: Pulmonary fibrosis PFD: Pirfenidone...
Our data will therefore be of value for drug discovery and biomarker research in the context of progressive fibrosing interstitial lung disease. Methods AAV vectors. Expression constructs harboring the murine TGF-β1 cDNA (NCBI Ref Seq NM_011577.2) with the constitutively activating mutations C...
Pulmonary fibrosis (PF) is a chronic interstitial lung disease with no effective therapies. Galectin-3 (Gal-3), a marker of oxidative stress, plays a key role in the pathogenesis of PF. Fibroblast-myofibroblast differentiation (FMD) is an important sourc
Senescence of alveolar epithelial cells impacts initiation and chronic phases of murine fibrosing interstitial lung disease. Front Immunol. 2022;13:935114. https://doi.org/10.3389/fimmu.2022.935114. Article CAS PubMed PubMed Central Google Scholar Zeng L, Yang XT, Li HS, Li Y, Yang C, Gu ...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease1,2 that is characterized by proliferation of fibroblasts and reconstruction of collagen (Col)-based extracellular matrix (ECM)3,4. Repetitive local injuries to an ageing alveolar epithelium is thought to play a...