Critical Care Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMPURPOSE: Bleomycin is feared for its induction of pulmonary toxicity, bleomycin-induced pneumonitis, organizing pneumonia or progression to interstitial lung fibrosis in 10%...
The mechanism of bleomycin-induced pneumonitis (BIP) involves oxidative damage, relative deficiency of the deactivating enzyme bleomycin hydrolase, genetic susceptibility, and the elaboration of inflammatory cytokines. Ultimately, BIP can progress to lung fibrosis. The diagnosis of BIP is established by ...
Lungs of bleomycin-treated WT mice display: severe pneumonitis; increased generation of superoxide; vascular leak; increased thrombin protein abundance and activity; activation of ERK; greater cytokine/chemokine release and infiltration with T-cells and macrophages. Lungs of STC1 Tg mice displayed none...
Bleomycin (BLM)-induced lung injury has become a model for studies of interstitial pneumonitis and pulmonary fibrosis. BLM induces lung injury in two phases: early inflammation characterized by infiltration of inflammatory cells into the lungs, followed by a late phase of fibrosis characterized by ...
et al. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am. J. Respir. Crit. Care Med. 173, 188–198. https://doi.org/10.1164/rccm.200504-644OC (2006). Article CAS PubMed Google Scholar Wang, J. et al. Chronic activation of the renin–...
AMI has been found to reduce the incidence and severity of radiation pneumonitis26,27,28. Multiple animal and preclinical studies have shown that AMI reduces damage to lung tissue29. Previous studies have also shown that down-regulation of TGF-β/SMAD-2 by AMI can inhibit EMT, reduce ...
In Korea, Pyunkang-hwan (Pyunkang-tang, PGT), a traditional herbal preparation consisting of a water extract from six herbs (Table 1), has been used for controlling hypersecretion of airway mucus in bronchitis, tonsillitis, pneumonitis and pulmonary fibrosis.19 Such information indicates that PGT...
Cell injury occurs through the formation of free radicals.Timely detection of bleomycin-induced pneumonitis (BIP) can be difficult and it is vi... SVD Brugge,HVR Claasen,L Dawson - 《Netherlands Journal of Critical Care》 被引量: 3发表: 2013年...
FDG-PET in bleomycin-induced pneumonitis following ABVD chemotherapy for Hodgkin’s disease-a useful tool for monitoring pulmonary toxicity and disease activity. Haematologica 2007, 92, e120–e121. [Google Scholar] [CrossRef] [Green Version] Connerotte, T.; Lonneux, M.; de Meeûs, Y.; ...
International Journal of Molecular Sciences Article Phosphatidylethanolamine Induces an Antifibrotic Phenotype in Normal Human Lung Fibroblasts and Ameliorates Bleomycin-Induced Lung Fibrosis in Mice Luis G. Vazquez-de-Lara 1,* , Beatriz Tlatelpa-Romero 1, Yair Romero 1 , Nora Fernández-Tamayo 1, ...