As we age, these changes can lead to altered gene expression and contribute to the development of age-related diseases such as cancer, Alzheimer's disease (AD) and cardiovascular disease (CVD). Conclusion: The discovery of aging biomarkers that are sensitive to these epigenetic changes has the ...
Proteomic Biomarker and Aging Signatures for Aggressive Human Metaplastic and other Breast Cancer Subtypes isolated from FFPE Tissues - GitHub - JoBBurt/Human-FFPE-Breast-Cancer-Subtypes: Proteomic Biomarker and Aging Signatures for Aggressive Human Met
Aging of the male prostate is an inevitable process in which the prostate undergoes hyperplasia, and this growth may lead to compression of the urethra, resulting in voiding dysfunction and associated symptoms, and an increased risk of prostate cancer. Despite the significance of prostate aging, the...
Large-scale epigenome-wide association meta-analyses have identified multiple ‘signatures’’ of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health re...
Chronic Diseases, Aging Application: Drug repurposing Phenotypic trait Chemosensitiviy Relevant Research: Accurate Blood-Based Diagnostic Biosignatures for Alzheimer’s Disease > Condition: Infectious Diseases Application: Lead identification Compound optimization ...
Intriguingly, the retina, which is embryologically derived from brain tissue, shows characteristic AD pathology (i.e., soluble amyloid β-peptide oligomers and plaque, phosphorylated tau and neurofibrillary tangles) well before the appearance of AD pathology in the brain [16,17,18,19,20,21,26,...
signatures to individual viruses including influenza, respiratory syncytial virus and dengue, but the generality of these signatures across all viral infection types has not been established. Based on 44 publicly available datasets and two clinical studies of our own design, we discovered and validated...
(2021). Identification and validation of ferroptosis-related lncRNA signatures as a novel prognostic model for colon cancer. Frontiers in Immunology, 12, 783362. Article CAS PubMed Google Scholar Yang, Y., Wang, Y., Guo, L., Gao, W., Tang, T. L., & Yan, M. (2022). Interaction...
3-Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme for ketone body synthesis, and most current studies focus on mitochondrial maturation and metabolic reprogramming. The role of HMGCS2 was evaluated in a pan-cancer multi-database
In attempts to unravel the etiology of AMD, to improve patient stratification, to monitor disease progression, and to discover new drug targets, manybiomarker studieshave been performed. In general, new analytical strategies have emerged, moving from single markers toward complex biomarker signatures, ...