In all models, the biological aging acceleration was associated with disease burden in persons with diagnosed chronic age-related conditions. For healthy individuals, the same quantity was associated with molecular markers of inflammation (such as C-reactive protein), smoking, current physical, and ...
Memory deficits associated with normal aging and Alzheimer’s disease have been linked to a decrease in the volume of brain structures, such as the hippocampus and to genetic markers, such as apolipoprotein E. In this regard, examination of CSF for biomarkers of disease can help in differentiatin...
Aging hypothesis, aging markers and the concept of biological age The following two points are made in this article: (1) the likely existence of more than one underlying cause of senescence strengthens the case for the de... DL Wilson - 《Experimental Gerontology》...
By contrast, if frailty can be related to biological markers of aging, these relationships should come closer to identifying the underlying factors that give rise to these functional declines. Within the frailty phenotype approach, the focus has been on clinical features of frailty; while it has ...
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(2012). Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21528–21533. Riddle, N. C., Minoda, A.,...
Several measures have been suggested, including the use of so named “bio-markers of aging” (Anstey et al. 1996, =-=Dean 1988-=-, McClearn 1997, Nakamura et al. 1998). A bio-marker of aging is an index of an organism’s physiological state. The rate of individual aging can be ...
10). We found that CALERIE intervention slowed the pace of aging, as measured by the DunedinPACE DNAm algorithm, but did not lead to significant changes in biological age estimates measured by various DNAm clocks including PhenoAge and GrimAge. Treatment effect sizes were small. Nevertheless, ...
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Inflammatory markers and gait speed decline in older adults. Increased inflammatory activity and gait speed decline are common with aging, but the association between the two is not well established. The objective of... Joe,Verghese,Roee,... - 《Journals of Gerontology》 被引量: 90发表: 2011...