Biology of the TAM Receptors 来自 Semantic Scholar 喜欢 0 阅读量: 122 作者: Lemke,G.摘要: The TAM receptors--Tyro3, Axl, and Mer--comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. Instead, they function as ...
芹菜素的治疗显示了在SKOV3卵巢癌细胞中克服TAM耐药性的潜力。有趣的是,Zhang等人最近报道,接受TAM和染料木素联合治疗的大鼠没有任何改善;然而,如果染料木素的消费始于青春期前或成年年龄,它显示出有益的影响。 植物雌激素与化疗 染料木素和大豆苷元显示了一种拮抗作用,联合使用髓母细胞瘤、乳腺癌和结肠癌细胞中...
The recent success of mRNA COVID-19 vaccines has sparked a surge in interest in RNA therapeutic technology and how the field of synthetic biology can be employed. Particularly, there are some challenges associated with RNA technology which can be addressed using synthetic biology. For example, bas...
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable’ in part due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic targ...
Materials and Methods: We performed histological analyses for hormone receptors (estrogen and progesterone receptors), HER2, and tumor infiltrating macrophages (TAM) on 17 breast cancers, obtained from Abia State University Teaching Hospital (Aba, Nigeria), between November 2008 and October 2009. On ...
Abbreviations: OAC, oesophageal adenocarcinoma; DC, dendritic cell; M1-Macro, M1-macrophage; TAM, tumour associated macrophage; MHC-I, major histocompatibility complex-I; NK-cell, natural killer cell. In cancers where targeted therapies have been more successful, genomic analyses of paired primary ...
Beijing Institute of Ophthalmology生物学前沿:英文版Qingxian L, Qiutang L, Qingjun L (2010) Regulation of phagocytosis by TAM recep- tors and their ligands. Front Biol (Beijing) 5:227-237Lu QX, Li QT, Lu QJ. Regulation of phagocytosis by TAM receptors and their ligands[J]. Front Biol,...
emerging data indicate that class I, II and class III-controlled pathways tightly regulate each other and can act as a rheostat for their respective pathways and functions (i.e., autophagy and AKT/mTOR pathway, but maybe other processes such as macropinocytosis of MHC-I surface receptors) (Fig...
Dynamic regulation of the tissue microenvironment by integrins and the extracellular matrix Guest editors: Dr. C. Michael DiPersio This special issue is focused on roles for the extracellular matrix or its integrin receptors in the cell’s ability to dynamically regulate the tissue microenvironment in...
et al. Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development 120, 2723–2748 (1994). Article CAS PubMed Google Scholar Mendelsohn, C. et al. Function of the retinoic acid receptors (RARs) during ...