Molecular docking analysis reveals that the gTLR21 ectodomain has the potential to distinguish between different ligands. Homodimer analysis results also suggest that Phe842 and Pro844 of the BB loop and Cys876
MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate...
In the more than 40 years since its discovery, a tremendous amount has been learned regarding the mechanisms that regulate the expression of both IL-2 and its cell surface receptor, its mechanisms of signalling and its range of biological actions. More recently, the mechanisms by which IL-2 ...
CD4+ T cells respond to either IL-10, IL-27, or IL-21 and acquire a Tr1 cell phenotype. IL-10, IL-27, and IL-21 promote STAT3 activation, and IL-27 promotes the pioneering factors IRF1 and BATF that prepare the Il10 locus for the binding of the transcriptional factors. The transcr...
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, γδ T cells, natural killer (NK), and NKT cells. IL-22 mediates its effectsviaa heterodimeric transmembran...
Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs Volatile methyl jasmonate from roots triggers host-beneficial soil microbiome biofilms Micropolarity governs the structural organization of biomolecular condensates A platform to induce and mature biomolecular condensates using chemicals...
The pro-inflammatory and anti-inflammatory properties of TNF are largely segregated by the capacity of this cytokine to bind to TNF receptor 1 (TNFR1) and TNFR2, respectively. The anti-inflammatory effects of TNF are explained by its capacity to increase the proliferation, stability and suppressiv...
Bovine lactoferrin enhances osteogenesis through Smad2/3 and p38 MAPK activation Toshihiro Inubushi, Azuma Kosai, Shyunryo Yanagisawa, Chea Chanbora, ... Takashi Takata June 2020 Pages 147-154 select article Effects of N-methyl-d-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostas...
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known cell death mechanisms. This process involves the interaction of...
This rate may be due to shortcomings of the aligner’s efficient yet heuristic algorithms [13]. Reads can also remain unmapped due to unknown transcripts [14], recombined B and T cell receptor sequences [15, 16], A-to-G mismatches from A-to-I RNA editing [17], trans-splicing [18],...