Mehta DS, Wurster AL, Grusby MJ: Biology of IL-21 and the IL-21 receptor. Immunol Rev 2004, 202: 84–95.Mehta, D.S., Wurster, A.L., and Grusby, M.J. (2004). Biology of IL-21 and the IL-21 receptor. Immunol. Rev. 202 , 84–95.Mehta DS, Wurster AL, Grusby MJ. ...
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bo
IL-2 was first identified as a growth factor capable of driving the expansion of activated human T cell populations. In the more than 40 years since its discovery, a tremendous amount has been learned regarding the mechanisms that regulate the expression
Here, we review what is currently known about the roles of these cytokines in T-cell immunity, in general, as well as in RA, in particular, focusing on recent discoveries. 展开 关键词: IL-7 IL-15 IL-7 receptor alpha IL-15 receptor alpha IL-2/15 receptor beta cytokines T-cell ...
Abstract Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, γδ T cells, natural killer (NK), and NKT cells. IL-22 mediates its effectsviaa heterodimeric ...
The pro-inflammatory and anti-inflammatory properties of TNF are largely segregated by the capacity of this cytokine to bind to TNF receptor 1 (TNFR1) and TNFR2, respectively. The anti-inflammatory effects of TNF are explained by its capacity to increase the proliferation, stability and suppressiv...
Keywords antiviral apoptosis cancer innate immunity pathogenesis receptor tropism vaccine virulence virus History Viruses exact an enormous toll on the human population and are the single most important cause of infectious disease morbidity and mortality worldwide. Viral diseases in humans were first noted...
The severity of experimental arthritis is independent of IL-36 receptor signaling Introduction Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36??, IL-36??, and IL-36??, that bind to the IL-36 receptor (IL-36R). IL... C Lamacchia,G Palmer,E Rodriguez… - ...
In MM, MM cells can secrete exosomes that MSCs can internalize, leading to upregulation of the expression of IL-8 [31]. This process relies on amphiregulin (AREG) packed into exosomes and its interaction with epidermal growth factor receptor (EGFR). According to the study, targeting EGFR ...
Aspartate in the tumour environment activates theN-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis. Ginevra Doglioni ,Juan Fernández-García &Sarah-Maria Fendt Research Briefing|18 December 2024 ...