Finally, we studied examples of complexes containing IDPs/IDRs that adopt a stable structure upon binding. IDRs often bind through short linear motifs (SLiMs), recognizing folded domains driven by a few residues. The longer IDRs can contain arrays of SLiMs and can also form stable structures upo...
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149, 753–767 (2012). This paper reconstituted RNA granules in vitro and revealed the role of LCDs in driving liquid-to-solid phase separation. Bose, M., Lampe, M., Mahamid, J....
Also, make sure you include all the important reactions in your notes as they are an important part of the NEET notes for Chemistry. The students must check all concepts which are included in the short form in the notes. Make sure you solve the NCERT problems before appearing in the ...
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regeneration phase. Five RIC markers of biological relevance were localized in the wound 1 dpa using in situ hybridization (Fig.3D; Additional file 2: Fig. S8). These markers are predominantly present in the regeneration bud, indicating that the RICs form an organizing center after the injury,...
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(10% < AF < 90%). This is consistent with the hypothesis that the majority of pMEIs are deleterious and under purifying selection. About 32% of pMEIs were within a TAD harboring oncogenes, tumor suppressor genes, or dosage-sensitive genes. In addition, 27.6% of pMEIs form a loop with...
Here, unexpectedly, we find that liquid–liquid phase separation, rather than nuclear localization, of recurrent patient-derived YAP fusions, YAP-MAMLD1 and C11ORF95-YAP, underlies ependymoma tumourigenesis from neural progenitor cells. Mutagenesis and chimaera assays demonstrate that an intrinsically ...
. The Seahorse XFe96 analyzer in the Saez laboratory (Scripps Research) was supported by 1S10OD16357. This is manuscript number 1072 from The Scintillon Institute. Author information Author notes Mina L. Heacock Present address: Calibr, The Scripps Research Institute, La Jolla, CA, USA ...