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Finally, we studied examples of complexes containing IDPs/IDRs that adopt a stable structure upon binding. IDRs often bind through short linear motifs (SLiMs), recognizing folded domains driven by a few residues. The longer IDRs can contain arrays of SLiMs and can also form stable structures upo...
Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation, rather than nuclear localization, of recurrent patient-derived YAP fusions,
1. Regular papers. Original full-length research papers which have not been published previously, except in a preliminary form, may be submitted as regular papers. 2. Short communications. These should not exceed 1200 words (three printed pages) or their equivalent, excluding references and legends...
(PCR), or assembling it from individual oligonucleotides. At the same time, a plasmid vector is prepared in linear form using restriction enzymes or PCR. The plasmid is a small, circular piece of DNA that is replicated within the host, and exists separately from the host’s chromosomal or ...
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The nascent cells of the ICM segregate to form the primitive endoderm (PrE) and the epiblast. These intricate processes, which are fundamental to early embryonic development, have historically been difficult to study in depth. However, recent advances in stem cell research have now made it ...
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149, 753–767 (2012). This paper reconstituted RNA granules in vitro and revealed the role of LCDs in driving liquid-to-solid phase separation. Bose, M., Lampe, M., Mahamid, J....