2a, Additional file 1: Figure S2a), which is the only gene within the TAD. This pMEI has a 10.4% AF, is in active chromatin regions, and does not form any loops with surrounding genes or their promoters. Fig. 2 Epigenetic and chromatin interactions near the candidate GSH sites in ...
Here, unexpectedly, we find that liquid–liquid phase separation, rather than nuclear localization, of recurrent patient-derived YAP fusions, YAP-MAMLD1 and C11ORF95-YAP, underlies ependymoma tumourigenesis from neural progenitor cells. Mutagenesis and chimaera assays demonstrate that an intrinsically ...
Author notes Ning Zhao and Zhao Geng contributed equally to this work. Authors and Affiliations Institute of Cotton, Hebei Academy of Agriculture and Forestry Sciences, Key Laboratory of Cotton Biology and Genetic Breeding in Huanghuaihai Semiarid Area, Ministry of Agriculture and Rural Affairs, Shiji...
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Downloadkeyboard_arrow_down Browse Figures Review ReportsVersions Notes Abstract Past-oriented rumination and future-oriented worry are two aspects of perseverative negative thinking related to the neuroticism endophenotype and associated with depression and anxiety. Our present aim was to investigate the gen...
Most proteins fold into 3D structures that determine how they function and orchestrate the biological processes of the cell. Recent developments in computational methods for protein structure predictions have reached the accuracy of experimentally determ
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The Notes are continuously updated. 1. Genes and Chromosomes Principles Chromosomes include dedicated sequences that ensure theirreplication, transcription, packaging, and transmission from one generation to the next. Chromosomes are large. Chromosomes in all cells are maintained in a state of torsional...
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consist
CCR4-NOT, the major de-adenylation complex, and its key adaptor protein BTG4 regulate translation downregulation often independent of RNA decay. BTG4 is not essential for global de-adenylation but is required for selective gene de-adenylation and production of very short-tailed transcripts. In sum...