Synonyms Metallo-β-lactamase superfamily ; Zinc metallohydrolase family of the β-lactamase fold Definition The metallo-β-lactamase superfamily was first defined in 1997 on the basis of a sequence alignment. The members of this superfamily are characterized by the presence of a common αββα ...
Proteins with a metallo-beta-lactamase (MBL) fold have been largely studied in bacteria in the framework of resistance to beta-lactams, but their spectrum of activities is broader. We show here that the giant Tupanvirus also encodes a MBL fold-protein that has orthologs in other giant viruses...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
VIM-1 is a new group 3 metallo-β-lactamase recently detected in carbapenem-resistant nosocomial isolates of Pseudomonas aeruginosa from the Mediterranean area. In this work, VIM-1 was purified from an Escherichia coli strain carrying the cloned bla VIM-1 gene by means of an anion-exchange chro...
F-spondin can also be fused with a reporter protein, such as alkaline phosphatase, horseradish peroxidase, 1-lactamase, B-galaetosidase, luciferase, green fluorescent protein, and the like. In 5 specific embodiments, exemplified infra, F-spondin is fused to immunoglobulins, myc or GST. In ...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
The metallo-beta-lactamase (M beta L) superfamily, which is intriguing due to its enzyme promiscuity, is a good model enzyme superfamily for studies of catalytic function evolution. Our previous study traced the evolution of the phosphotriesterase activity of the M beta L superfamily and found ...
The first crystal structure of an archaeal metallo‐β‐lactamase superfamily protein; ST1585 from Sulfolobus tokodaii[J] . AtsuhiroShimada,HirohitoIshikawa,NorikoNakagawa,SeikiKuramitsu,RyojiMasui.Proteins . 2010 (10)Shimada A, Ishikawa H, Nakagawa N, Kuramitsu S, Masui R. The first crystal ...
1. An anti-TGFbetaRII immunoglobulin single variable domain comprising the amino acid sequence of SEQ ID NO: 267. 2. An anti-TGFbetaRII immunoglobulin single variable domain as claimed in claim 1, wherein the anti-TGFbetaRII immunoglobulin single variable domain further comprises a C-terminal ...