Laboratory of Gene Structure and ExpressionThe EMBO journalAntoniou M et al.The humanβ- globin gene contains multiple regulatoryregions:identification of onepromoter and two downstream enhancers. EMBO Journal . 1988Antoniou M, deBoer E, Habets G, Grosveld F. The human beta-globin gene contains ...
The human β-globin gene Locus Control Region (LCR), a dominant regulator of globin gene expression, is a contiguous piece of DNA with five tissue-specific DNase I-hypersensitive sites (HSs). Since these HSs have a high density of transcription factor binding sites, structural interdependencies ...
This suggests that the major component of Chinese has a unique primary structure. A minor component of the new was completely different from that of the other three haplotypes well known. These results indicate that the and of the new haplotype, assigned Hbbw1, are unique genes in their ...
The β and δ chains of hemoglobins A and Aare very similar in structure and are encoded by genes that are tightly linked, yet in the red cell β chain production is 40 fold greater than production of the δ chain, providing an excellent model for studying the control of gene expression...
Structure and FunctionReferences LAR Confers Position-Independent, High-Level Expression of the Human Beta-Globin Gene in Transgenic Mice LAR Confers Powerful Transcriptional Enhancing Activity LAR Activates Homologous and Heterologous Promoters in Tissue-Specific Manner LAR Is Highly Conserved in Its Organiza...
Immune globin receptors FccRIIb and PirB Two immune globin receptors, FccRIIb and PirB, originally believed to function exclusively in the immune system, were recently shown to play neuropathic roles as Aβ receptors in Alzheimer's disease brains[97, 127, 128]. These two proteins show ...
Beta-globin gene mutations which alter normal globin RNA splicing have confirmed the necessity of invariant nucleotides GT at donor splice sites. Functional consequences of point mutations in the invariant AG acceptor splice site have not been determined. We have isolated and characterized a beta-globi...
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Human β-globin mRNA precursors (pre-mRNAs) synthesized in vitro from a bacteriophage SP6 promoter/β-globin gene fusion are accurately and efficiently spl... AR Krainer,T Maniatis,B Ruskin,... - ...
Two immune globin receptors, FccRIIb and PirB, originally believed to function exclusively in the immune system, were recently shown to play neuropathic roles as Aβ receptors in Alzheimer's disease brains97,127,128. These two proteins show similarity in their structures and in the high binding...
2. Chromosome localization and structure of alpha and beta globin gene clusters (for details see text). gion, containing also a strong enhancer, maps 50 Kb from the beta globin gene (Fig. 2). This region, dubbed locus control region (LCR), contains four (HS-1 to HS-4) erythroid ...