Genetics Beta-globin gene cluster haplotypes in sickle cell diseasepolymorphisms of the Arab Indian haplotype BOSTON UNIVERSITY Martin SteinbergMaryann Macneil GesiottoQuintoThe HbS gene had a limited number of origins during history, and these can be defined by the haplotype (a set of DNA ...
Here, novel tag SNPs on beta -globin gene cluster in Chinese Han population was reported on using Haploview 4.2. The haplotype block and LD analysis showed three blocks that were constructed with 35 common SNPs. All common SNPs were generated with the Tag SNPs using Haploview's Tagger with ...
网络类β珠蛋白基因簇 网络释义 1. 类β珠蛋白基因簇 gene-英汉词典... ...beta like globin gene cluster[医]类β珠蛋白基因簇bithorax comples gene [医]果蝇的双胸复合基因 ... www.fastdict.net|基于 1 个网页
Expression regulation of the beta-globin gene cluster is a result of synergistic interactions between cis-elements and trans-acting factors. Previous studies usually concentrated on the core sequence of each hypersensitive site in the locus control region of the beta-globin gene cluster. But more and...
1. High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster [J] . Lv X, Xu DD, Liu DP, Biochemistry and Cell Biology . 2002,第6期 机译:高迁移率族蛋白2可能参与β-珠蛋白基因簇的基因座控制区调控 2. Beta-globin gene swit...
In view of the presence of a large number of mutations associated with the disease, the polymorphic markers present in the β-globin gene cluster region were commonly used in linkage analysis of the disease. Markers usually show a population-based dependent haplotype frequency. Among the ...
Amplicon library preparation in parental and trophoblast DNA Five overlapping long (7–17.7 kb) PCRs were performed with either parental or trophoblast DNA to select the 62.7 kb region of the β-globin gene cluster (Supplementary Figure 2). The PCR conditions and the primers sequences are ...
The human beta-globin locus is a highly complex genetic system that has become a classical model for studying the regulation of eukaryotic gene expression. The locus consists of five functional beta-like globin genes, epsilon- Ggamma-Agamma-delta-beta and a powerful upstream regulatory element, ...
The globin gene clusters of Xenopus laevis are interspersed by various different repetitive DNA elements. A specific repeat, the JH12 element, has been mapped by Southern analysis and some of its locations have been subsequently confirmed by nucleotide sequencing. JH12 family members seem to represen...
From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil β-globin gene (ω) in the marsupial α-cluster, however, suggested that duplication of the α-β cluster onto two ...